Summary

This document discusses herbal medicine for obesity, highlighting various plant-based remedies and their potential mechanisms to combat obesity. It examines different targets for weight reduction, including metabolic rate, glucose levels, and lipid profiles. It also reviews the effectiveness of various ingredients like ginger, pomegranate, and caffeine, emphasizing their potential effects on appetite suppression and metabolic rate.

Full Transcript

Treating obesity is important, because by treating it, you will solve a group of diseases such as diabetes, heart-related diseases, lipid profile, reproductive system, or she can’t get pregnant. We can tell her that she must lose weight to solve the problem. —-> so underlying causes for very frequen...

Treating obesity is important, because by treating it, you will solve a group of diseases such as diabetes, heart-related diseases, lipid profile, reproductive system, or she can’t get pregnant. We can tell her that she must lose weight to solve the problem. —-> so underlying causes for very frequent and commonly accruing diseases Obesity may be caused by genetic disorders ( history of the disease in family) , or by underlining disease ( insulin resistance, lipid profile) or by drugs ( antidepressants, cortisone , multivitamin ) or caused by wrong lifestyle, low rate of metabolism, the output less than intake of energy ( doesn't play sports just eat food ) Herbal Medicine for Obesity Dr. Deniz Al-Tawalbeh Three targets or mechanism for plant sources to reduce the obesity: 1- act on metabolic rate 2- glucose levels and insulin resistance 3- lipid profile And use something to appetite suppressant which is good—> as drinks plenty amount of water ( feel fullness, increase metabolism rate ) According to the WHO, one in five people is obese , especially in children Treating obesity is important, because by treating it, you will solve a group of diseases such as diabetes, heart-related diseases, lipid profile, reproductive system, or she can’t get pregnant. We can tell her that she must lose weight to solve the problem. —-> so underlying causes for very frequent and commonly accruing diseases Obesity may be caused by genetic disorders ( history of the disease in family) , or by underlining disease ( insulin resistance, lipid profile) or by drugs ( antidepressants, cortisone , multivitamin ) or caused by wrong lifestyle, low rate of metabolism, the output less than intake of energy ( doesn't play sports just eat food ) Herbal Medicine for Obesity Dr. Deniz Al-Tawalbeh Three targets or mechanism for plant sources to reduce the obesity: 1- act on metabolic rate 2- glucose levels and insulin resistance 3- lipid profile And use something to appetite suppressant which is good—> as drinks plenty amount of water ( feel fullness, increase metabolism rate ) According to the WHO, one in five people is obese , especially in children What is obesity? Obesity: is defined as the abnormal or excessive fat accumulation that presents a risk to health. It is the most common nutritional disorder in industrialized countries and is becoming increasingly prevalent in developing countries due to changing lifestyles One of the most used methods to assess obesity is the body mass index, a person’s weight (in kilograms) divided by the square of his or her height (in meters). ETIOLOGY 1- Energy imbalance: the imbalance between Diet and Exercises. 2- Genetics: polygenic, each gene having a small contribution in the presence of precipitating environmental factors. 3- Diseases like hypothyroidism. 4- Drugs: (antidepressants, antiepileptics, tricyclic antidepressants, lithium, valproate, carbamazepine). Apple vinegar increases metabolism rate Green tea speeds up metabolism rate but does not make you feel full and after 2 weeks cause dependence. GINGER Drink it before meal to get the activity, and amount of tea is with each meal, before meal by 30 min The 3 major ways by which ginger contribute to weight loss are: 1. By improving digestion: promotes the quick absorption of essential body nutrients 2. By speeding up metabolism as much as 20%. 3. Suppresses the appetite: By providing a feeling of “fullness” or satiety Ginger can cause stomach problems. In our ethnopharmacology , but must stop use POMEGRANATE PEELS pomegranate because it contains high amounts of tannins ( toxic for the body) Some studies indicated pomegranate peel extract Can reduce glucose levels but not recommended to be induces weight loss in mice, due to its effect on used for weight reduction reducing serum triglyceride and plasma glucose Cause malnutrition, loss iron, calcium …and constipation concentration The satiety hormone (leptin hormone) to be CAPSIACIN secreted and reaches the brain, giving a signal of satiety need 20 minutes —> so you must Studies have found that capsaicin can increase your prolong meal , take your meal in at least 20-30 metabolism, which increases the rate at which you use energy and burn fat stores. minutes, Chew food slowly, not swallow leptin —> hormone act directly on CAPSIACIN increase the sensitivity of leptin hormone , may brain ,mechanism of : cause irritation in stomach and constipation , hemorrhoids Body send sensors to brain that the fat mass is getting low , sugar levels low, leptin hormone is low —> brain sends sensors to feel hangry When you eat, the leptin levels increase—> send CINNAMON signals to brain that the fat mass increases and glucose levels increase, —> send signals that According to studies, cinnamon may facilitate feel fullness weight loss by enhancing insulin sensitivity and This mechanism needs 20 minutes lowering blood sugar levels. Among overweight people, insulin resistance is a prevalent issue that can result in weight gain And Control the hormone in females WHITE KIDNEY BEANS Carb blocker White Kidney Bean Extract is known for supporting weight loss, reducing carb absorption, assisting with starch blocking; works by blocking the enzyme that breaks carbohydrates down into glucose during digestion In our digestive system, we have an enzyme called Alpha amylase enzyme, whose function is to break down carbohydrates and convert them into easily absorbed sugars. These sugars, when not excreted, turn into fats in the body. White beans bind to amylase enzymes and block them, so when we eat carbohydrates, they will not be absorbed and will remain large in size and exit the body ( diet rich with carbohydrates) The caffeine structure name is Xanthine , its pseudo alkaloids , why pseudo alkaloids? Because it’s not from amino acid, and the N in the cycle (contains heterocycle ) CAFFEINE CAFFEINE:stimulant , —> Block receptors responsible for fatigue , caffeine prevents adenosine receptors binding. After a while, tolerance develops, and the body reacts by increasing the production of adenosine receptors. Caffeine increases resting metabolic rate, which means it The dependence is not based on quantity, but on increases the number of calories burn at rest. The effect also frequency. appears to decrease with age and is greater in younger To break the dependence—> reducing the assumption individuals of coffee to the half or duplicate it. In one study, caffeine had an appetite-reducing effect in men, but not in women, making them eat less at a meal following caffeine consumption. However, another study showed no effect for men Because females take chocolate with coffee, unlike males who take cigarettes, in addition to eating food while staying up late. Whether coffee or caffeine can help lose weight in the long term may depend on the individual. At this point, there is no evidence of such long-term coffee drinkers (due to tolerance). Not effective product , effect cardiovascular system GREEN COFFE BEANS Green coffee bean extract comes from coffee beans that haven’t been roasted. Coffee beans contain compounds known as chlorogenic acids. Some believe these compounds have antioxidant effects, help lower blood pressure, and help lose weight. Roasting coffee reduces chlorogenic acid content. Green coffee beans contain chlorogenic acids, which are caffeic acid and quinic acid , and ester link —> if you roast it —> breaks the bond —> convert to product with low amounts of chlorogenic acid , high amounts of caffeine so caffeine is acting Chlorogenic acid act on lipid profile and metabolism rate and as antioxidants ( found in topical preparations for anti aging and Skin care products ) Not effected as products for weight reduction, it’s antioxidant, poly phenolic structure, improved lipids profile but If the problem in weight gain not lipid profile, it will not affect weight loss. It speeds up the metabolism rate , but not much. Not effective product alone Increase metabolism, increase burn of fats and antioxidants, use before the meal, Three servings or according to the number of meals , a cup, not a glass GREEN TEA Effective if it’s a lifestyle,if you take it before the meal it will reduce the size of meals, increase metabolism, not effective alone and without sugar The caffeine and catechins it contains have been shown to boost metabolism and increase fat burning ✨ ‫ و& عباله‬shape in ‫✨& بيعمل‬ Pineapple : rich in fibers and Nutritionists recommend one slice of pineapple, and it should be natural, not canned.use as snack To satisfy hunger and provide the body with fiber PINAPPLE bromelain enzyme act on fat in the body, help to burn fat especially in billy area The flesh of pineapple is a decent source of fiber, which tends to fill up and eventually ends up inducing a sense Increase metabolism ( not too much) , Prevents of satiety. protein absorption Pineapple contains an enzyme called bromelain. This Not very good, may have malabsorption, as snack enzyme is found helps in metabolizing protein, which in is good just turn helps burn away the excess belly fat Fruit snacks should be one type only, not a salad. Glucomannan may lead to modest weight loss in overweight individuals, mainly by creating a feeling of fullness and reducing calorie. Guar plant; Part used: seeds, Constituents: high fiber content, Actions: fibers of guar gum bind to fats and eliminate them with feces. Glucomannan Green coffee: antioxidants , increase metabolism but not the essential in weight loss Guar gum is fibers Glucomannan may lead to modest weight loss in The idea of ADIPs is that when we take it, weindividuals, overweight feel full. In addition, mainly if you by creating takeof it with a a feeling fullness and reducing calorie. diet full of fats before eating, it draws fats and removes them from the body without absorbing them. It may cause diarrhea, soft stools andGuar plant; ,Part gasses used: seeds, bloating, Constituents: cramps and bad highsmell fiber of stool content, Actions: fibers of guar gum bind to fats and and whitish ( because it’s fatty) eliminate them with feces. As studies, the risk of guar gum over wise the benefits Glucomannan : polysaccharides, When it enters the stomach, it swells and becomes a gel-like structure. It makes you feel full, stops you from eating a lot, and reduces appetite. Glucomannan alone is enough Contraindicated in pregnancy and breast feeding ( all drugs is contraindicated) Adips not the best choice How does a pregnant woman maintain her weight? Healthy eating rich in vitamins and exercise with control. Glucomannan —> Structure full of amines ( NH2) , when NH2 enter the stomach convert to positively charged structure so , it will bind with any negative charge fatty acid —> CHITOSAN forming complex and take it out the body, Suitable for people with fat dependency In pharmaceuticals preparations use as binder , drugs Chitosan is a sugar that comes from the outer skeleton of delivery, and coating, nanoparticles , and it’s shellfish, including crab, lobster, and shrimp antibacterial, anticancer Its positively charged nature results in binding to free fatty acids (released from consumed fat) and bile salt components which results in disrupted lipid absorption in the gut APPLE VINEGAR Proponents of apple cider vinegar claim that it has numerous health benefits and that drinking a small amount or taking a supplement before meals helps 500ml water with 3-4 drops of apple curb appetite and burn fat. cider vinegar just ( safe amount) ,increase metabolism rate, take However, there's little scientific support for these it before eating by 30 min , effective as claims. Studies of apple cider vinegar for weight loss have not consistently shown significant and routine sustainable weight loss across diverse groups of Act by two mechanisms, the water people. makes you feel fullness, apple cider vinegar increases metabolism rate Although occasional use of apple cider vinegar is If you take it in large quantities or safe for most people, it does carry some risks. For tablets , you must be careful. It may example: cause irritation in the stomach and throat because it is an acidic *Apple cider vinegar is highly acidic. It may irritate compound. your throat if drink it often or in large amounts. And if patients have chronic disease as diabetes, hypertension, take diuretics— *Apple cider vinegar may interact with certain > don’t take apple cider vinegar may supplements or drugs, including diuretics and cause interactions between drugs insulin. This may contribute to low potassium levels. L-CARNITINE CHROMIUM L-carnitine is an amino acid derivative Chromium may potentiate the action of that transports fatty acids into your insulin by increasing insulin sensitivity cells to be processed to energy. and maintaining blood sugar profile. It works to transport fats and enter the cell and Side effects: nightmerse and headache, moodiness convert them into energy. If you take it and especially in females exercise, it will be effective. Without exercise, it is not effective. Take before exercise by 30 min , very powerful and very effective Ingredients: Chitosan. Ginger. Apple vinegar. Cinnamon. Pomegranate. Capsaicin. Chromium Very powerful product, act on insulin sensitivity, lipid profile and, leptin , metabolism rate and fullness Keep attention to the contraindications Expensive Act as guar gum , prevent fat absorption so the same side effects of guar gum, the difference between them : ORLISTAT doesn’t give to children under 18 years , guar gum doesn’t give to children under 12 ORLISTAT years Before the meal , suitable for patients with deit rich fat Orlistat can inhibit the gastric and pancreatic lipase enzyme. Chia seeds and matcha, Act as guar gum , prevent fat absorption so the same side effects of guar gum, the difference between matcha is available themin: ORLISTAT the formdoesn’t of teagive or to a product, matcha children under 18 yearsis ,the guarsame as green gum doesn’t tea give to or green children under 12 ORLISTAT coffee years beans, it is a product with a high content of caffeine, at first it reduces weight then the Before the meal , suitable for patients with deit rich fat body becomes dependent, it increases the metabolism rate if the person has a good lifestyle Orlistat can inhibit the gastric and Chia seeds are very pancreatic lipaseeffective enzyme. and rich in nutrients, they contain a high content of protein and fiber, the problem is that they can cause weight gain if eaten without exercise, in the long run they can cause liver toxicity and contraindications with hypertension patients and patients with diuretics, if you are one of the people who are likely to develop gallbladder diseases it causes exacerbation for symptoms, so the gallbladder may explode, It may cause intestinal obstruction and chronic constipation. yes it is useful but we must use it in the right way , add on lifestyle Liver and kidneys should be checked to avoid any side effects

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