HEMA 2 LEC RQ CHAPTER 35, 37, 38 PDF

​ REVIEW QUESTIONS: CHAPTER 35, 37, 38 PRML142: Hematology 2 Lecture || CMBERMIDO Bachelor of Science in Medical Technology | BSMT3J | S2 2024-2025 CHAPTER 35 Glanzmann...

​ REVIEW QUESTIONS: CHAPTER 35, 37, 38 PRML142: Hematology 2 Lecture || CMBERMIDO Bachelor of Science in Medical Technology | BSMT3J | S2 2024-2025 CHAPTER 35 Glanzmann A defect in GP IIb/IIIa causes: thrombasthenia What intimal cell synthesizes and Abnormal platelet Patients with Bernard-Soulier Endothelial cell stores von Willebrand factor (VWF)? response to syndrome have which of the ristocetin following laboratory test findings? What subendothelial structural Tissue factor protein triggers coagulation through Which of the following is the most activation of factor VII? Storage pool common of the hereditary platelet defects function defects? What coagulation plasma protein Fibrinogen should be assayed when platelets fail Altered expression to aggregate properly? A reduction in thrombin generation in of phospholipids on patients with Scott syndrome results the platelet Carboxylates the from: What is the primary role of vitamin K membrane factors to allow for the prothrombin group factors? calcium binding Decreased numbers The impaired platelet function in of alpha granules myeloproliferative neoplasms results Thrombin What is the source of prothrombin and dense granules from: proteolysis of fragment F1.2? fibrinogen Impaired membrane The platelet defect associated with activation, owing to What serine protease forms a increased paraproteins is: protein coating Factor IXa, factor X complex with factor VIIIa, and what is the substrate of this complex? In uremia, platelet function is NO impaired by higher than normal What protein secreted by endothelial TPA levels of: cells activates fibrinolysis? Thrombocytopenia associated with What two regulatory proteins form a Anti-GP IIb/IIIa the use of cardiopulmonary bypass is APC and protein S complex that digests activated antibodies not caused by: factors V and VIII? Aspirin ingestion blocks the synthesis Mediate platelet Thromboxane A2 of: adhesion and serve as a carrier What are the primary roles of VWF? A mechanism of antiplatelet drugs molecule Direct binding to GP targeting GP IIb/IIIa for factor VIII IIb/IIIa function is: Most coagulation factors are Ehlers-Danlos Which is a congenital qualitative The liver synthesized in: syndrome platelet disorder? Lead to the The events involved in secondary formation of a hemostasis: CHAPTER 38 stable fibrin clot Which of the following coagulation The autosomal dominant disorder factors is activated by thrombin and May-Hegglin Factor XIII associated with decreased platelet mediates the stabilization of the fibrin anomaly production is: clot? Large overactive Which of the following is not a Which of the following endogenous platelets hallmark of ITP? plasma inhibitors is (are) important AT, TFPI for the control of excessive thrombin The specific antigen most commonly generation? HPA-1a responsible for the development of NAIT is: A 2-year-old child with an CHAPTER 37 unexpected platelet count of Acute ITP 15,000/uL and a recent history of a Bleeding into the The clinical presentation of viral infection most likely has: joints platelet-related bleeding may include (hemarthroses) all of the following except: 1 REVIEW QUESTIONS: CHAPTER 35, 37, 38 PRML142: Hematology 2 Lecture || CMBERMIDO Which drug causes a reduction in Anagrelide platelet count by inhibiting megakaryocyte maturation? A defect in primary hemostasis Mucosal bleeding (platelet response to an injury) often results in: The combination of When a drug acts as a hapten to the drug and the induce thrombocytopenia, an platelet membrane antibody forms against which of the protein to which it is following? bound Abnormal bone formation, including TAR refers to: hypoplasia of the forearms The mother has an autoimmune antibody to her own platelets, which Neonatal autoimmune crosses the thrombocytopenia occurs when: placenta and reacts with the infant’s platelets Diarrhea caused by HUS in children is associated with: Shigella species Treatment with an anticomplement Atypical HUS agent such as eculizumab is first-line therapy for: Thrombocytosis is Which of the following statements self-correcting regarding thrombocytosis is not true? 2