Guiding Questions Lecture 7 PDF

LECTURE 7 GUIDING QUESTIONS : Q1: Decide whether each of these statements is true or false and justify your answer. 1. Gorge Mendel discovered that sarcomas could likewise be transmitted between chickens by injection of filtered tumor extracts. 2. Common feature shared by many oncogeni...

LECTURE 7 GUIDING QUESTIONS : Q1: Decide whether each of these statements is true or false and justify your answer. 1. Gorge Mendel discovered that sarcomas could likewise be transmitted between chickens by injection of filtered tumor extracts. 2. Common feature shared by many oncogenic viruses is the ability to conceal themselves inside cells. 3. Only upon exposure to a physically stressful situation does the latent virus become activated and cause cancer. 4. Rous v-src gene have been detected in the normal cellular DNA of a wide variety of organisms 5. Retroviral Oncogenes Are Altered Versions of Normal Cellular Genes 6. Epstein-Barr Virus is an RNA, a virus that can cause cancer. 7. Human papillomavirus (HPV) is a virus responsible for cervical cancer. Of the more than 100 different types of HPV, only a small number cause cancer 8. Types 16, 20 in Human papillomavirus can cause cancer. Q2: Discuss briefly. 1. Experiment led to discovery of Rous sarcoma in brief (the 4 steps) 2. Discovery of v-src gene by peter vogt 3. 2 types of Retroviruses causing cancer 4. 2 Mechanisms of viruses that cause latent infections (Latent, DNA virus and reteroviruses) 5. Possible Origin of Retroviral Oncogenes 6. Avian myelocytomatosis, and Myc protein 7. How to write genes and protein names in human and virus 8. Avian leukosis viruses – and insertion mutagenesis (mechanism to cause cancer) 9. long terminal repeat’s role in retroviruses 10. Epstein-Barr Virus mechanism to cause Burkitt’s lymphoma. 11. Human-papillomavirus mechanism to cause cancer. 12. Low-risk types of HPV and High-risk types of HPV Q3 complete the following. 1. The v-Src protein have a constitutively active function is to …………………………….(all the highlighted in red)The normal Src kinase is…………………………….. (all the highlighted in red) 2. The SV40 virus, for example, produces a single protein called the ………………. that accomplishes both tasks, binding to and incapacitating both the ……………… and the ………………. Protein causes cancer. 3. In Gene Therapy. Retrovirus can integrate itself into a chromosome near a normal gene called ……………, whose abnormal expression is known to be associated with certain forms of …………………. 4. Acutely transforming retroviruses such as……………………and Slow-acting retroviruses such as…………………………