Dovamil Gentle+ LF Infant Formula PDF

Positive Impact on Future Generations Dovamil products training GENTLE+ LF  a What is infantile colic ? colic are paroxysms of irritability, fussing or crying that occur in otherwise healthy infants for...

Positive Impact on Future Generations Dovamil products training GENTLE+ LF  a What is infantile colic ? colic are paroxysms of irritability, fussing or crying that occur in otherwise healthy infants for > 3 hours a day on > 3 days a week for > 3 weeks Peak at 3 months of age “Rule of Three” originally proposed by Wessel and colleagues  a Infantile colic is the most common reason to visit pediatricians in the first 3 months 10-30% of infants worldwide is affected  a Possible causes (theories) for infantile colic Underdeveloped Imbalanced Transit Lactase and Alerted gut mucosal barrier gut microbiota Enterokinase motility insufficiency  1 Causes of Infantile colic Gut Hormones and hyperperistalsis Higher levels of ghrelin and motilin were found in infants affected by colic, even though further studies are required to clarify their role in infantile colic Gut Hormones and hyperperistalsis Motilin Function: Stimulates the migrating motor complex (MMC), a pattern of muscle contractions that clears the stomach and small intestine. In Colic: Some studies suggest that infants with colic may have abnormal motilin signaling, leading to irregular MMC activity. Gut Hormones and hyperperistalsis Ghrelin Function: Appetite stimulant, released when the stomach is empty. In Colic: Elevated ghrelin levels have been reported in infants with colic, potentially contributing to increased hunger and discomfort. a Research suggests enzyme activity may be reduced in infants at birth LACTASE ENTEROKINASE Enzyme that breaks down lactose Activates enzymes that break down proteins ONLY 25% ACTIVE ONLY 70% ACTIVE Lactase insufficiency If lactose in the intestine exceeds the intestinal absorptive capacity (3.5g/100ml or above 4.5g/Kg/day), excess of lactose will pass into the colon to be fermented with colonic bacteria.  Diagnosis Diagnosis depends on exclusion of other causes of colic and it’s differential diagnosis Treatment Parents advise and reassurance about the nature of colic and follow the 5 S approach. Treatment Lactobacillus reuteri ATCC 55730 and its daughter strain Lactobacillus reuteri DSM 17938 to breastfed infants is well tolerated and improves symptoms of infantile colic. ( Savino, 2010)  Treatment Dietary first-line approach is represented by formulas based on partially hydrolyzed whey proteins  a GENTLE+ PLUS Special infant formula for colic & gases 0-12 months Low lactose  a GENTLE+ PLUS CARBOHYDRATES Reduced lactose 14% ???? HMOs prebiotics (2-FL) Maltodextrins 85%  a Low lactose to solve lactase insufficiency reducing bacterial fermentarian and subsequent reduction of gas formation Lactose is replaced with more easily digested maltodextrins  a Biological effects of HMOs a a  a HMOs prebiotics Reduced colic, fussiness and crying Improves GI maturation episodes Enhances intestinal barrier development + Promotes growth of gut microbiota Improve GI function & immunity Reverri EJ, Devitt AA, Kajzer JA, Baggs GE, Borschel MW. Review of the Clinical Experiences of Feeding Infants Formula Containing the Human Milk Oligosaccharide 2'- Fucosyllactose. Nutrients. 2018 Sep 21;10(10):1346. doi: 10.3390/nu10101346. PMID: 30241407; PMCID: PMC6213476.  a GENTLE+ PLUS PROTEINS Easy-to-digest partially hydrolyzed proteins (whey protein hydrolysate)  a Add 2 rectangles for MFGM & HMOs  a MFGM lipids Reduced colic, fussiness and crying Contributes to intestinal trophism episodes Supports intestinal maturation + Enhance growth of healthy microbiota Improve GI function Improves gut immunity & immunity Fontecha J, Brink L, Wu S, Pouliot Y, Visioli F, Jiménez-Flores R. Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well- Being. Nutrients. 2020; 12(6):1607. https://doi.org/10.3390/nu12061607 a Benefits of Beta-palmitate Reduced crying time Increased intestinal microbiota a Benefits of Beta-palmitate 1 Reduced the total soaped excreted FA Increased Bone mineral density and 2 improves overall growth 3 Reduced crying time & better tolerability 4 Bifidogenic effect with GOS prebiotic  a LC-PUFAs DHA & ARA Omega-6 Omega-3 Vegetable oils, Salmon, tuna, Long-chain margarine, Nuts, sardines, mackerel, seeds, grains, flaxseed & chia polyunsaturated fatty meats seeds acids (LC-PUFAs) Linoleic acid a-Linolenic acid Compete for the same enzyme converting enzyme in the body Gamma-linolenic Eicosopentaenoic acid acid Arachidonic acid Docosahexaenoic acid (ARA) (DHA)  a Manage feeding issues, and help mom build a stronger bond with her infant Calm infant crying, and bring mom and baby more happy moments together with Dovamil Gentle *Berseth CL, Johnston WH, Stolz SI, Harris CL, Mitmesser SH. Clini Pediatri (Phila), 2009 Jan;48(1):58-65  a shown to quickly relieve gas and fussiness *Berseth CL, Johnston WH, Stolz SI, Harris CL, Mitmesser SH. Clini Pediatri (Phila), 2009 Jan;48(1):58-65  a ® GENTLE+ PLUS Provides easy-to-digest broken down proteins It has 85% less lactose than standard infant formula It has HMOs prebiotics that enhance gut function and microbiota It is supplemented with unique MFGM lipid that promotes gut maturations and immunity Provide all nutrients baby needs to learn, grow and develop. Main Competitors Similac X Novalac Primilac Bebelac Comfort Gentle AC AC EC Or LF Gentle Colic : Lactose Free Formulas? It is highly important to highlight that colic is due to excess of lactose in the colon and not to lactose by itself: 30-35% of ingested lactose can be absorbed. The colic problem remains in the excess of lactose that exceeds the capacity of lactase. Colic : Lactose Free Formulas? Lactose is a disaccharide playing important role in infants’ growth and development: In fact, babies need lactose: To supply 40% of energy needs To facilitate calcium absorption To facilitate iron absorption To reduce risk of GI infections For healthy growth and development Thus, lactose cannot be deprived from infants ‘diet for a long period. Else, it will be causing serious problems in infants ‘growth. Colic : Lactose Free Formulas? The less the lactase enzyme is stimulated; the more the risk of developing lactose intolerance in the future: Lactose free formulas cause a decrease in lactase activity; thus, leading to lactase deficiency which may be the reason of developing lactose intolerance Lactose free formulas are not convenient for long term use Colic : Lactose Free Formulas? Lactose free formulas are not adapted for management of colic: 1- colic is due to excess of lactose 2- LFF are not convenient for long term use: ➔If lactose is deprived from infants ‘diet for a long period, it will be causing serious problems in infants ‘growth. ➔ Lactose free formulas cause a decrease in lactase activity  a DOVAMIL LF Infant formula for lactose intolerance 0-12 months  a Diarrhea It refers to the passage of loose or watery stools Diarrhea (WHO definition): is the passage of three or more loose or watery stools per day Lactose intolerance – A clinical syndrome in which ingestion of lactose or lactose-containing food causes symptoms (abdominal pain, bloating, flatulence, nausea, diarrhea). Lactose intolerance may or may not be associated with lactose malabsorption Causes of secondary lactase deficiency: - Infection: like rotavirus, giardiasis - Mucosal injury: celiac, inflammatory bowel disease and drug or irradiation-induced enteritis - Small intestinal bacterial overgrowth Diagnostic test for lactose intolerance/malabsorption Hydrogen breath test: a lactose solution is ingested by the patient and serial breath samples are collected to measure hydrogen levels Villous Atrophy Common causes: 1. Infection ( Rota virus) 2. Allergy ( cow milk protein allergy) 3. Autoimmune ( Celiac disease). a  a DOVAMIL LF CARBOHYDRATES Completely lactose-free with almost 0 lactose residues 100% maltodextrin  a DOVAMIL LF PROTEINS Easy-to-digest partially hydrolyzed proteins (whey protein hydrolysate) to prevent allergy to cow’s milk during diarrheal episode.  a 1-4 Role of Zinc in diarrhea Many studies recommend zinc supplementation for all children with diarrhea resulting in: a shorter duration of diarrhea reduces the number of stools and stool output reduces the risk of persistent diarrhea, and may reduce the risk of subsequent illness and increase weight gain 10mg for infants less than 6months. 20mg for infants more than 6months.  a DOVAMIL LF Has proven efficacy in reducing symptoms in diarrhea associated with lactose intolerance It meets all the nutritional requirements of infants up to 1 year It is proven to prevent the development of atopic dermatitis and other atopic symptom in infants at risk to CMP Furthermore, it can also prevent atopic symptoms in non-at-risk infants group. Fortified with zinc to support gut immune function  a References 1. Savino et al. Italian Journal of Pediatrics 2014, 40:53 http://www.ijponline.net/content/40/1/53 2. Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLoS One 2010;5(4):e10386-e10386 3. Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121:326-336.. 4. Brooks WA, Santosham M, Roy SK, et al. Efficacy of zinc in young infants with acute watery diarrhea. Am J Clin Nutr 2005;82:605-610. 5. Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr 2004;38:34-40.