General Physiology 01 - Class Notes PDF
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Uploaded by AwedEllipse6283
Prarambh
Dr. Vivek Nalgirkar
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Summary
These lecture notes cover general physiology for first-year students. Topics include body fluids, measurement techniques, and disturbances in body fluid compartments. The notes are well-organized and include diagrams and key concepts.
Full Transcript
# PRARAMBH - Physiology MedEd - 1st Year Batch ### Lecture-01 - General Physiology By :- Dr. Vivek Nalgirkar ## Topics to be Covered 1. Introduction 2. Body Fluids 3. Measurement of Body Fluid Volumes 4. Disturbances In Body Fluids 5. 6. ## Body fluid Compartments * Body fluids measurement....
# PRARAMBH - Physiology MedEd - 1st Year Batch ### Lecture-01 - General Physiology By :- Dr. Vivek Nalgirkar ## Topics to be Covered 1. Introduction 2. Body Fluids 3. Measurement of Body Fluid Volumes 4. Disturbances In Body Fluids 5. 6. ## Body fluid Compartments * Body fluids measurement. * Disturbances (Physiott) ## Body Fluid Compartments * **TBW**= 60% of Body wt 70-ks = ∼242 L * **ICF** = 40% of Body wt 13 = ∼28.1 L * **ECF** = 20% of Body wt 3/th = ∼14 L **ECF** > Interstitial fluid > Plasma > ∼ 3 L plasma > → ∼5 L > > **Blood** 8% of Body wt > **Transcellular fluid** = 1 L > **[Pleural, synovial, ... ]** ## Measurement > Indicator dilution method > * A known initial val. (I) is injected > * Evenly dispersed > * Sample collected To measure concentration(C) > **V=I/C** > V = volume of compartment > I= Initial vol. indicator > C= Concentration of indicator > A= Amount of indicator that left ## Indicators Used 1. **TBW**:- * Deuterium oxide (D2O) * Tritium (3H20) * Antipyrine * Aminopyrine 2. **ECF**:- * Non-metabolizable saccharides * Sucrose * Mannitol * INULIN 3. **Icf - (TBW)-(ECF)** * **BLOOD** * Plasma :- * Evans blue (T? 1824) * Radiolabelled albumin * Cells:( 1125) (1/3) I * Cr - Tagging of red cells ## Physio++ ## Disturbances in body fluid compartments * **Loss / Dehydration** * **Gain / Overhydration** ### Primary change (of volume) is in ECF > **Osmolality of ECF may change** > secondary change in ICF [shift of water from ICF to ECF, ECF dict] ## Dehydration > **Hypertonic** > **Isotonic** > **Hypotonic** 1. **Isotonic dehydration** * G.I. fluid loss * Bame. 2. **Hypertonic dehydration** * D.D.M. * Diabetes insipidus * Alcoholism * Lithium salts ### Darrow-Yennet diagrams. * **300 mOsm** * **ICF ECF** * **↑ 28L 14L** * **300 mOsm** * **ICF ECF** * **↑ 28L 14L** ## Thank You MedEd
