Drugs Combating Acute Inflammation PDF

Drugs Combating Acute Inflammation Your Name: 1. What is the primary reason NSAIDs lead to gastric irritation and ulceration? 2. How do selective COX inhibitors (Coxibs) differ from traditional NSAIDs regarding gastric safety? 3. What role do proton pump inhibitors play in managing NSAID- induce...

Drugs Combating Acute Inflammation Your Name: 1. What is the primary reason NSAIDs lead to gastric irritation and ulceration? 2. How do selective COX inhibitors (Coxibs) differ from traditional NSAIDs regarding gastric safety? 3. What role do proton pump inhibitors play in managing NSAID- induced injuries? 4. Why can paracetamol be considered different from NSAIDs in terms of its mechanism of action? 5. What potential risk does the use of selective COX inhibitors pose to patients with cardiovascular issues? 6. Why is chronic use of NSAIDs not preferred despite their effectiveness in acute inflammation? 7. Explain the significance of differentiating between COX-1 and COX-2 inhibition in NSAID therapy. 8. What are the three main clinical effects of NSAIDs as mentioned in the content? 9. How do the prostaglandins (PGs) produced by COX-2 relate to the inflammatory process? 10. What is the role of COX-1 in the body that makes its inhibition potentially harmful? 11. What classification is sometimes used to differentiate NSAIDs from opioid analgesics? 12. State one potential advantage of using selective COX-2 inhibitors over non-selective NSAIDs. 13. In what types of conditions are NSAIDs typically used clinically? 14. Why might the use of NSAIDs in managing chronic conditions be limited? 15. Identify a specific side effect of inhibiting COX-1 while using NSAIDs. 16. What are the main chemical classes of drugs that suppress prostaglandin production in acute inflammation? 17. How do corticosteroids suppress prostaglandin production? 18. In what way do non-steroidal anti-inflammatory drugs affect the arachidonic acid pathway? 19. What are the potential risks of inhibiting prostaglandins in various tissues? 20. Why might corticosteroids be considered effective for both inflammation and allergic responses? 21. What role do COX enzymes play in the pharmacological inhibition of prostaglandin synthesis? 22. How do both corticosteroids and NSAIDs differ in their mechanism of action against inflammation? 23. In what circumstances might one combine corticosteroids or NSAIDs with antimicrobial drugs? 24. What are the two main categories of NSAIDs? 25. How do reversible non-selective COX inhibitors differ from irreversible ones? 26. Why is aspirin's antiplatelet action maintained for the lifetime of the platelet? 27. What is the primary modern clinical use of aspirin, and why? 28. Which NSAID is considered the most effective analgesic and what is its drawback? 29. What distinguishes ibuprofen from ketorolac in terms of efficacy and tolerance? 30. What is the role of thromboxane and prostacyclin in the context of aspirin's mechanism of action? 31. What are the risks associated with non-selective COX inhibitors compared to selective agents? 32. At what doses does aspirin provide analgesic versus anti- inflammatory effects? 33. What kind of medications are included in the category of reversible non-selective COX inhibitors?