Drug Structure, Function & Properties
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Uploaded by ProficientRapture7037
Robert Gordon University
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Summary
This document covers the principles of drug structure, function, and properties. It details the key aspects of drug-target interactions, protein structure, and various bonding forces. The document also explains the importance of structure-activity relationships and how pharmacophores relate to drug design. The document concludes with an explanation of Lipinski's rule of five.
Full Transcript
**[Drug Structure, Function & Properties]** Key focuses: 1. Have a general understanding of how and where drugs interact. 2. Have an appreciation for protein structure and know the forces involved in controlling protein structure. 3. Differentiate between the different types of bonding fo...
**[Drug Structure, Function & Properties]** Key focuses: 1. Have a general understanding of how and where drugs interact. 2. Have an appreciation for protein structure and know the forces involved in controlling protein structure. 3. Differentiate between the different types of bonding forces between drugs and targets - Recognise hydrogen bond donors/acceptors and evaluate different functional groups as hydrogen bond donors/acceptors 4. Understand Structure/Activity Relationships. 5. Understand what a pharmacophore is. **[Molecular Characteristics of Good Drugs]** 1. Be able to apply Lipinski's Rule of Five (note: all parameters are multiples of 5, hence the name!) - Poor absorption (or permeation) is more likely when: - The molecular weight is over 500 - The log P is over 5 - There are more than 5 H-bond donors (expressed as the sum of OHs and NHs) - There are more than 10 H-bond acceptors (expressed as the sum of Ns and Os).
