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. MAOIs Blocks enzymes that are responsible for the breakdown of 5-HT, NE, & DA The mechanism of action for MAOI-As is that it breaks down 5-HT, SA, NE, & tyramine. Confusion, dizziness, insomnia, sedation, & vivid dreams are common side effects of MAOIs MAOIs are the last choice medicat...

. MAOIs Blocks enzymes that are responsible for the breakdown of 5-HT, NE, & DA The mechanism of action for MAOI-As is that it breaks down 5-HT, SA, NE, & tyramine. Confusion, dizziness, insomnia, sedation, & vivid dreams are common side effects of MAOIs MAOIs are the last choice medication class for depression because of the many potential serious side effects & have specific dietary restrictions. MAOI-A is used an an Antidepressant and Anxiolytic MAOI- B is used to treat Parkinson's disease. Which food needs to be avoided when taking an MAOI? Foods that contain tyramine= red wine, sauerkraut, aged cheese, soy, smoked meats, preserved foods, tap and unpasteurized beers, smoked fish, kimchee, tofu Why are certain foods avoided when taking MAOIs? MAOIs break down tyramine in the gut. Ingesting extra tyramine puts the patient at an increased risk of a hypertensive crisis. Serotonergic agents should be avoided when taking MAOIs because it increases the risk of serotonin syndrome. Wait 5 half-lives after discontinuing a serotonergic medication before starting an MAOI. Monamine oxidase-A (MAOI-A) is an enzyme in humans that is encoded by the MAOA gene that is used to treat depression & anxiety.