Monoclonal Antibody Therapies for Cancer PDF
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Uploaded by CharitableCerberus1189
University of Nottingham
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Summary
This document discusses various monoclonal antibody strategies for cancer treatment, including examples and their effects. It also covers different types of antibodies, like antibody-drug conjugates and radiolabeled antibodies.
Full Transcript
Monoclonal antibody strategy Examples Effect Blocking of signal or stimulated Trastuzumab Anti-HER2 function internalization and apoptosis Pertuzumab Anti-HER2 dimerization...
Monoclonal antibody strategy Examples Effect Blocking of signal or stimulated Trastuzumab Anti-HER2 function internalization and apoptosis Pertuzumab Anti-HER2 dimerization Rituximab Anti-CD20 – causes induction of apoptosis, lysis and phagocytosis Anti-CD47 turns off ‘don’t eat me’ signal Magrolimab Antibody-drug conjugates Trastuzumab-deruxtecan Anti-HER2 + topoisomerase inhibitor Anti-HER2 + tubulin inhibitor Trastuzumab-emtansine Radiolabelled antibodies Anti-PSMA-Lutetium-177 DNA damage and apoptosis from 𝛃 and 𝛄 irradiation. Bispecific monoclonal antibodies CD3 and CD20 bispecifics Targeted cell death of tumours cells by T CD3 and PSMA bispecifics cells. CD3 and HER2 bispecifics Carcinoma associated Function antigen HER2 Receptor tyrosine kinase EPCAM Epithelial cell adhesion molecule PSMA Prostate specific membrane antigen CD19, CD20 B lymphocyte antigens
