D- Biology 3 PDF
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Uploaded by CharitableCerberus1189
The University of Nottingham
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Summary
This document contains information on gene dysregulation. It includes examples of splicing mutations, gene deletions, amplifications, rearrangements and single nucleotide mutations, which are all connected to cancer.
Full Transcript
Regulation Examples * Splicing mutations RB1 Suppressing Gene deleti...
Regulation Examples * Splicing mutations RB1 Suppressing Gene deletions (removal of regions of EGFR, INK4, ARF DNA) ↳ removal of amino acid domain Hyrusine Kinase) Gene amplifications (increased copy MDM2 number) Chromosome rearrangements Philadelphia chromosome BCR/ABL, BCL2 Single nucleotide mutations at critical P53, RAS, EGFR sites - coding process leaves nucleus wraped t Histoneeons big Piece of DNA * RBI no longer inhibit -Factor PS3 Pathway > - & coces graninea de factors the weeknd * Gene amplification guaninerange Factor * good Y *
