Biology 2 PDF
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Uploaded by CharitableCerberus1189
The University of Nottingham
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Summary
This document appears to be a biology research document focusing on cancer and receptors. It details different compounds, their targets, and associated cancers. It also discusses tamoxifen's role in modifying estrogen receptors.
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↑ growth factor - > proliferation...
↑ growth factor - > proliferation breast Cancer causes ↳ initiate cell death it > - no ligandactivates t * Compound Trade name Target Cancer Imatinib Gleevec BCR-ABL Chronic myeloid leukaemia (CML) Gefitinib Iressa EGFR Non small cell lung carcinoma (NSCLC) Sorafinib Nexavar VEGFR, Renal cell carcinoma PDGFR, RAF Sunitinib Sutent VEGFR, Renal cell carcinoma PDGFR, KIT Lapatinib Tykerb EGFR, HER2 HER2+ breast cancer Vandetanib Caprelsa RET, VEGFR Medullary thyroid cancer Ruxolitinib Jakafi JAK1/2 Myelofibrosis Venurafenib Zelboraf BRAF (V600 Metastatic melanoma mutant) acid change amino - (mutation) - * * Tamoxifen : antagonise production of genes promoted by AFL agonist for genes Promoted by AE
