Crystals & Amorphous Solids Student Notes PDF

Crystalline & Amorphous Solids Dr Lynda Storey Room: N548 X2528 [email protected]  Summary of Last Lecture Intermolecular forces influence many physicochemical properties (e.g. Mpt, solubility, shape & crystal structure). Intermolecular forces are to do with posit...

Crystalline & Amorphous Solids Dr Lynda Storey Room: N548 X2528 [email protected]  Summary of Last Lecture Intermolecular forces influence many physicochemical properties (e.g. Mpt, solubility, shape & crystal structure). Intermolecular forces are to do with positive & negative charges, partial charges & induced charges. Intermolecular forces determine drug-target interactions. The refractive index is a measure of the speed of light through a substance and can be used to help identify that substance.  Homework from last lecture A pure substance has an angle of incidence of 48.41 and an angle of refraction of 34.13 at 20 C using a wavelength of 589 nm. The substance is 20 n D A Methanol 1.329 B Water 1.333 C Ethanol 1.362 D Benzene 1.501  Homework What intermolecular forces are at play between these two molecules: O O O O H O H O  Learning Objectives Describe the two types of solid – crystalline & amorphous. Describe the different shapes (morphology) of crystals and how they are relevant to pharmacy. Distinguish between solvates & hydrates.  Solid State – Two Types Crystalline - ordered arrays of ions, atoms or molecules held together by electrostatic or non- covalent forces. - well defined faces & edges Amorphous - no ordering present among the constituent basic particles - a powder - curved surfaces, globular  Crystalline Solids Amorphous Solids Narrow (