DNA Replication: A Comprehensive PDF

Initiation of DNA replication: The Replicon Model of Replication Initiation Origin of replication The specific sites at which DNA unwinding and initiation of replication occur Replicon All of the DNA replicated from a particular origin of repli- cation as a replicon. Replicator As the cis-acting...

Initiation of DNA replication: The Replicon Model of Replication Initiation Origin of replication The specific sites at which DNA unwinding and initiation of replication occur Replicon All of the DNA replicated from a particular origin of repli- cation as a replicon. Replicator As the cis-acting DNA sequences that are sufficient to direct the ini- tiation of DNA replication Initiator This protein specifically recognizes a DNA element in the replicator and acti- vates the initiation of replication Replicator Sequences Include Initiator-Binding Sites and Easily Unwound DNA DnaA T antigen ORC Functioning of replication machinery in prokaryotes Regulation of DNA replication in prokaryotes Multiple replicators in eukaryotes Assembly of pre-replication complex in eukaryotes Activation of helicase and assembly of eukaryotic replisome Regulation of DNA replication in Eukaryotes Regulation of DNA replication in Eukaryotes Replication termination in prokaryotes Replication termination in Eukaryotes Protein priming Telomerase Telomere binding proteins Yeast Human T-Loop formation