Lehninger - Chapter 23: Integration of Metabolism PDF
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Temple University
Marc A. Ilies, Ph. D.
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This document is a chapter on integration of metabolism, part of a larger textbook, and focuses on the concepts of metabolism at the whole organism level, including specific tissues, hormonal regulation, and the effects of over-nutrition.
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Integration of metabolism Marc A. Ilies, Ph. D. Lehninger - Chapter 23 [email protected]; lab 517, office 517A (Tu, Fr 3-5) For questions, comments please use the discussion tool in Canvas ©MAIlies2024...
Integration of metabolism Marc A. Ilies, Ph. D. Lehninger - Chapter 23 [email protected]; lab 517, office 517A (Tu, Fr 3-5) For questions, comments please use the discussion tool in Canvas ©MAIlies2024 1 Pathways of carbohydrate-, amino acid-, nucleotide- and lipid metabolism illustrated in previous sections Hormonal and neuronal signals integrate and coordinate the metabolic activity of different tissues/organs 2 Metabolism at the whole organism level In previous lectures, we focused on metabolism at the cellular level. – role and mechanism of specific enzymes – flux of metabolites through pathways – feedback regulation of metabolic pathways – transport of metabolites across organelle membranes In this chapter, we will focus on metabolism at the whole organism level. – role (and structure) of specific tissues and organs – flux of metabolites from organ to organ – hormonal regulation of metabolism – control of body mass Neuronal versus hormonal signaling In neuronal signaling, nerve cells release neurotransmitters that act on nearby cells. Distance may be small (
