Cerebra Odollam (Cardiac Poison) PDF
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Dr. Vasant Parikh Ayurvedic Medical College
Dr Jayanti Jain
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This presentation provides information on Cerebra odollam, a plant with toxic properties, including its botanical name, family, English names, and regions where it's found. The presentation also details the toxic chemical constituents, mode of action, signs and symptoms, fatal dose and period, treatment, and post-mortem examination. Lastly, it covers medico-legal aspects related to its use.
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CEREBRA ODOLLAM (CARDIAC POISON) DR JAYANTI JAIN (BAMS, MD ) ASSISTANT PROFESSOR DR VASANT PARIKH AYURVEDIC MEDICAL COLLEGE, VADNAGRA INTRODUCTION Botanical Name – Cerebra odollam Family- Apocynace...
CEREBRA ODOLLAM (CARDIAC POISON) DR JAYANTI JAIN (BAMS, MD ) ASSISTANT PROFESSOR DR VASANT PARIKH AYURVEDIC MEDICAL COLLEGE, VADNAGRA INTRODUCTION Botanical Name – Cerebra odollam Family- Apocynaceace English Name – Suicide tree, Buddha tree, Sea Mango, pong-pong, othalanga The plant grows in wet areas in South India, Madagascar and Southeast Asia. The fruit Resembles Mango and its kernel (core of the fruit) contains various toxic principles. 2 TOXIC CHEMICAL CONSTITUENT (ACTIVE PRINCIPLE) Cerberin Cerberoside Nerifolin 3 MODE OF ACTION Cerberin has a mechanism of action similar to digoxin (binds and inhibit Na+, K+ ATPase in cardiac myocytes); Hence, its toxicity is similar to acute digoxin poisoning. 4 SIGN AND SYMPTOMS Toxic effects resemble those produced by digitalis. ◆ On ingestion, there is bitter taste, nausea, vomiting, chest pain, palpitations, bradycardia, syncope, hyperkalemia, thrombocytopenia and ECG abnormalities. ◆ Death is due to 'heart attack' produced by the poison. 5 FATAL DOSE & FATAL PERIOD FATAL DOSE FATAL PERIOD Kernel of one fruit 12-24 hr 6 TREATMENT Supportive therapy for bradycardia and hyperkalemia (similar to digoxin toxicity) Atropine followed by temporary cardiac pacing. Administration of digoxin immune Fab Extracorporeal membrane oxygenation. 7 POSTMORTEM EXAMINATION Non-specific changes. i. Signs of GIT irritation may be seen. ii. Stomach and duodenum may be congested and may show fragments of seeds. iii. Congestion of visceral organs is seen 8 MEDICO -LEGAL ASPECTS It is used both for suicide and homicide. i. Common suicidal agent in Kerala (more in females). ii. It can be used for homicide as kernel may be added to toddy, liquor or food to disguise its bitter taste. Accidental poisoning can occur from eating the fruit by mistake. 9
