Cell Injury PDF

- Types of irreversible cell injury - Pathologic basis of apoptosis - Pathologic basis of necrosis - Types of necrosis  Types of cell injury Cell death Cellular swelling t Fatty change Irreversible cell injury ...

- Types of irreversible cell injury - Pathologic basis of apoptosis - Pathologic basis of necrosis - Types of necrosis  Types of cell injury Cell death Cellular swelling t Fatty change Irreversible cell injury  Irreversible cell injury Red blood cells Irreversible cell injury Decreases size of tissues  Irreversible cell injury Microscopic picture:  Irreversible cell injury Definition: Death of large groups of cells or tissues within the living body. It occurs either directly or follows reversible injury  Irreversible cell injury Causes:  Irreversible cell injury Microscopic picture: Nuclear changes Cytoplasmic changes  Irreversible cell injury Types:  Irreversible cell injury Types: 1-Coagulative necrosis - The most common type - Caused by ischemia (cutting of arterial blood supply). - Affect all organs except brain. - Preserving the outlines of the cells and tissue architecture  Irreversible cell injury Types: 2-Liquefactive necrosis - Occurs in the brain - Caused by ischemia (cutting of arterial blood supply). - The affected tissues become structureless due to rapid liquefaction by enzymes released from necrotic cells and neutrophils  Irreversible cell injury Types: 3-Caseous necrosis - Induced by cell mediated immunity - Most common example is tuberculosis (T.B) - The affected tissues become yellowish cheesy like - Combination of coagulative and liquefactive necrosis  Irreversible cell injury Types: 4-Fat necrosis A- Enzymatic: - Occur in acute pancreatitis - -Escape of lipase enzyme which cause digestion of peritoneal fat B-Traumatic: - Occur in breast due to trauma - -The fat cells rupture and self digestion occur - -Clinically: Hard breast mass misdiagnosed as cancer  Irreversible cell injury Fate: Lymphatics Engulfed by macrophages Drained by lymphatics Irreversible cell injury 1. Which of the followings is characteristic for apoptosis: a. Always pathologic c- Could be physiologic or pathologic. b. Death of large group of cells. d- The affected cells are enlarged. 2- Which of the following types of cell injury is surrounded by inflammation: a. Cloudy swelling c- Fatty change b. Apoptosis d-Necrosis