Cardiovascular Pharmacology PDF

CARDIOVASCULAR PHARMACOLOGY Introduction Heart pumps blood to lungs & systemic circulation Heart efficiency can be impaired by: Compromised contractility (heart failure)  drugs for heart failure Heart rhythm disturbances  antiarrhythmics Heart attack (angina pectoris)  antiangina...

CARDIOVASCULAR PHARMACOLOGY Introduction Heart pumps blood to lungs & systemic circulation Heart efficiency can be impaired by: Compromised contractility (heart failure)  drugs for heart failure Heart rhythm disturbances  antiarrhythmics Heart attack (angina pectoris)  antiangina Chronic increase of BP  antihypertension ANTIHYPERTENSIVE AGENTS (AH) AETIOLOGY  AGE  RACE How to measure BP Hypertension (HT)  Hypertension (HT) = SBP > 140 and/or DBP > 90 mmHg  Two types   Secondary HT  treated with causal th/  Primary HT  treated with anti HT (AH)  Has fatal consequences : stroke, MI (Myocardial infarction), renal failure Non Pharmacolgic management  Dietary of Hypertension modifications (DASH )  regular exercise,  weight management,  stress reduction  limiting alcohol consumption.  Smoking cessatin Pharmacologic management of HT Primary HT  initial monotherapy Unsuccessful  polypharmacy Drug choices: involving different group to maximize efficacy & minimize side effects Severe, malignant HT  hospitalization AH Classification There are 4 major drug groups: Diuretics Sympatholytics Vasodilators Angiotensin antagonists CARDIO-METABOLIC PHARMACOLOGY