BS31013 - Biophysical Properties of Nav1.5 - myDundee PDF
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Uploaded by ShinyLongBeach6025
University of Dundee
Dr Claire Y Hepburn
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Summary
This document is a lecture presentation on the biophysical properties of Nav1.5, focusing on genetic polymorphisms and their clinical implications. It explores the various aspects of sodium channels, including their function, structure, and the role they play in heart conditions. The presentation also details various experimental techniques for studying cardiac electrophysiology
Full Transcript
Barc J., et al. (2022). "Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. " Nat Genet 54: 232-239. Erratum in: Nat Genet. 2022 May;54(5):735. S, O. B., et al. (2022). "Increa...
Barc J., et al. (2022). "Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. " Nat Genet 54: 232-239. Erratum in: Nat Genet. 2022 May;54(5):735. S, O. B., et al. (2022). "Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels." J Mol Cell Cardiol 166: 23-35. O'Reilly, M., et al. (2023). "Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide." Europace 25(3): 1152-1161. O'Shea C., et al. (2022). "High resolution optical mapping of cardiac electrophysiology in pre-clinical models." Scientific Data 9: 1-12. doi: 10.1038/s41597-022-01253-1. Wisedchaisri, G., et al. (2019). “Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel." Cell 178: 993–1003. α β 1; Ito 0mV 0; INa 2 3, IKr 4 -100mV Dong et al., Front Physiol., 2020; 11 Adapted from de Lucia, Eguchi and Koch. Front. Pharmacol., 2018; 9,904. Cardiovascular Physiology Concepts, 3e, 2022 Wisedchaisri et al., Cell., 2020; 178 Dong et al., Front Physiol., 2020; 11 1; Ito 0mV 0; INa 2 4 -100mV Barc et al., Nat Gen., 2022; 54 Barc et al., Nat Gen., 2022; 54 O’Shea et al., Sci. Data., 2022; 9 Barc et al., Nat Gen., 2022; 54 Li et al., Front. Physiol., 2019; 10, 1-8 α O’Reilly et al., Europace., 2022; 25, 1152-1161 O’Brien et al., JMCC., 2022; 166, 23-35 O’Brien et al., JMCC., 2022; 166, 23-35
