BIOL2022 Immunology, Infection and Inflammation Introduction 2025 PDF

Immunology, Infection and Inflammation BIOL 2022 Wood engraving of Louis Pasteur watching Joseph Meister receiving the rabies vaccine. From Harp...

Immunology, Infection and Inflammation BIOL 2022 Wood engraving of Louis Pasteur watching Joseph Meister receiving the rabies vaccine. From Harper’s weekly 29: 836 Course Co-ordinator Jessica Teeling E-Mail: [email protected] Southampton General hospital TEL: 02381-206301, room LD80c The course Introduction to basic immune mechanisms -basic principles of immunology 1 -the cells and molecules of the immune system -innate and adaptive immune system -immune system in disease -viral infection 2 -bacterial infection -parasite infection -autoimmunity 3 -exploiting of the immune system to study and treat disease - Vaccines Guest lectures: (clinical) immunologists  PART 1 Learning Outcomes of basic principles of immunology 1. Recognise the key cells and mediators of the innate immune system and the mechanism of their recruitment to sites of inflammation. 2. Outline how innate immune cells respond to pathogens and cytokines. 3. Define the roles of B and T lymphocytes in acquired immune responses.  Part 2 Learning Outcomes of immune system in disease 1. Describe how pathogens can cause disease and identify the strategies adopted by bacteria, such as enterohaemorrhagic E.coli. 2. Define how infection with the HIV-1 virus can lead to AIDS and describe the therapeutic strategies to prevent clinical progression 3. Describe the immune responses associated with parasitic infections 4. Identify how lack of immune tolerance can lead to autoimmune diseases.  Part 3 Learning Outcomes of exploiting of the immune system 1. Explain the principle of vaccination and outline its historical origins. 2. List different types of vaccines and compare and contrast their beneficial properties or limitations. Lectures: Lectures will be held on Tuesday 12:00-13:00 and Wednesday 9:00-10:00 in Building 100 room 1001 Building 32 room 1015 Mid semester MCQ and End of Module exam Mid semester MCQ: 20% End of Module written exam: MCQ (20%)+ 2 diagram questions (60%) TIMETABLE LECTURES: Lectures will be held on Monday 15-16 and Tuesday 14-15in Building 32, room 1015 Wk Date Time Staff Lecture Information 28-Jan 12:00-13:00 JT Introduction and Innate immunity - part 1 1 29-Jan 9.00-10:00 JT Innate immunity - part 2 4-Feb 12:00-13:00 JT Innate Immunity - part 3 2 5-Feb 9.00-10:00 EF Adaptive immunity T cells – part 1 11-Feb 12:00-13:00 EF Adaptive Immunity T cells – part 2 3 Guest lecture 12-Feb 9.00-10:00 JA 18-Feb 12:00-13:00 EF Adaptive Immunity B cells – part 1 4 Adaptive Immunity B cells – part 2 19- Feb 9.00-10:00 EF 25-Feb 12:00-13:00 CWK Bacterial infection 5 26-Feb 9.00-10:00 4-Mar 12:00-13:00 CWK Viral infection 6 5-Mar 9.00-10:00 11-Mar 12:00-13:00 JT Autoimmunity 7 12-Mar 9.00-10:00 w/c 17- tbc JT Mid-semester MCQ exam 7 Mar tbc Highfield campus Computer workstations 18-Mar 12:00-13:00 NS Parasite Infection 8 19-Mar 9.00-10:00 25-Mar 12:00-13:00 Vaccines 9 26-Mar 9:00-10:00 EASTER VACATION (29 MAR-28 APRIL) 29 April 12:00-13:00 TBC Immunology 10 30 April 9:00-10:00 6-May 12:00-13:00 TBC Immunology 11 7-May 9:00-10:00 13-May 12:00-13:00 all Revision 12 14-May 9:00-10:00 ü Humoral immunity is also called: 1 antibody-mediated immunity 2 non-specific immune response 3 antigen mediated immunity 4 all of these Click HERE to go to the library page for tips on studying and past papers Mid-semester MCQ exam Computer-based In-person w/c 17th March TBA  Recommended texts Janeway’s Immunobiology by Janeway Kuby Immunology. Kindt, Goldsby, Osborne. (Freeman) Excellent texts for introductory and revision synopsis for many aspects of this and other Immunology courses. Multiple copies of these (plus other general Immunology texts) are available in the short loan collection Books will be useful for Biol3037 If you have an issue with the module who can you talk to? There are many options: 1. Let us know during the session (sound, lighting, picture quality, etc.) 2. Talk to / or email the lecturer directly 3. Email the Module Coordinator ([email protected]) 4. Provide comments / issues / improvements to your Student Rep for the Student Staff Liaison Committee (SSLC) meeting 5. Email the Director of Student Experience 6. Complete the Module Evaluation Questionnaire (mid/end of semester)  A brief introduction to our immune system Role of the immune system (IS) Defence (of host) against threat of disease by pathogenic infectious organisms (pathogen) IS complexity due to range of organisms encountered – evolved to deal with many challenges IS protects against tumours (some) Vaccines offer exciting new hopes for infections and cancer therapy Chronic immune responses can cause disease, for example sepsis, autoimmunity, Type-2 Diabetes Cells of the Immune system ADAPTIVE INNATE the two arms of the immune response Innate immunity the immediate response to infection Awareness – detection of pathogens to signal their presence Immediate response – resident tissue cells/factors and the recruitment of cells from the blood – chemical signals generated Signals sent to the acquired response for provision of immunity-long lasting - the  Which of the following is a unique component of the innate―but not adaptive―immune system? 1. immune “memory” 2. natural killer cells ü 3. phagocytosis 4. specificity https://www.youtube.com/watch?v=jeN8v5I5VNA