Bulk or Vesicular Transport PDF

Lesson 4.4 Bulk or Vesicular Transport General Biology 11/2 Science, Technology, Engineering, and Mathematics Eggs, milk, and meat are rich sources of proteins. 2  Proteins help our body for muscle development, improved immune system, bone development, and metab...

Lesson 4.4 Bulk or Vesicular Transport General Biology 11/2 Science, Technology, Engineering, and Mathematics Eggs, milk, and meat are rich sources of proteins. 2  Proteins help our body for muscle development, improved immune system, bone development, and metabolism. Proteins are one of the essential macromolecules needed for different cellular processes. 3 How do large molecules such as proteins pass through the cell? 4 Learning Competency At the end of the lesson, you should be able to do the following: Explain the transport mechanisms in cells (bluk or vesicular transport) (STEM_BIO11/12-Ig-h-14). 5 Learning Objective At the end of the lesson, you should be able to do the following: Explain the process of bulk or vesicular transport. 6 How do cells transport large molecules? 7  Bulk or Vesicular Transport Vesicles These are structures within or outside a cell, consisting of a cytoplasm and enclosed by a lipid bilayer. Structure of a vesicle 8  Bulk or Vesicular Transport Vesicles These are formed naturally during the process of secretion, uptake, and transport of molecules. Structure of a vesicle 9  Bulk or Vesicular Transport Golgi Bodies The Golgi body often produces the vesicles that carry these cell products to the membrane. Golgi bodies producing transport vesicles 10  General Mechanism of Bulk Transport Budding Scission Uncoating Translocation Tethering Fusion Bulk or vesicular transport general mechanism 11  General Mechanism of Bulk Transport Coat proteins bind to sorting signals A selected cargo undergoing the general steps of bulk transport 12  General Mechanism of Bulk Transport A soluble cargo is selected A selected cargo undergoing the general steps of bulk transport 13  General Mechanism of Bulk Transport The membrane deforms and it forms a “bud” containing the molecule. A selected cargo undergoing the general steps of bulk transport 14  General Mechanism of Bulk Transport Scission proteins help release the coated vesicle containing the selected material. A selected cargo undergoing the general steps of bulk transport 15 General Mechanism of Bulk Transport The coat proteins are removed through the process of uncoating. A selected cargo undergoing the general steps of bulk transport 16 General Mechanism of Bulk Transport Determine whether it is a correct target. A selected cargo undergoing the general steps of bulk transport 17 General Mechanism of Bulk Transport The vesicle will move closer to the target membrane for fusion. A selected cargo undergoing the general steps of bulk transport 18 General Mechanism of Bulk Transport The vesicle delivers its membrane components then it physically fuses with the target membrane. A selected cargo undergoing the general steps of bulk transport 19 Tips Generally, bulk transport has six steps. These are budding, scission, uncoating, translocation, tethering and fusion. To remember these six steps easily, you may just use the acronym, Bu-Sci-Un-Tra-Te-Fu or BSUTTF. 20 How are the types of vesicular transport different from one another? 21 General Mechanism of Bulk Transport Exocytosis Types of Phagocytosis Vesicular Transport Pinocytosis Receptor-mediated endocytosis 22  Types of Vesicular Transport Exocytosis Types of Phagocytosis Vesicular Transport Pinocytosis Receptor-mediated endocytosis 23  Types of Vesicular Transport Exocytosis Types of Phagocytosis Vesicular Transport Pinocytosis Receptor-mediated endocytosis 24  Types of Vesicular Transport Exocytosis Types of Phagocytosis Vesicular Transport Pinocytosis Receptor-mediated endocytosis 25  Types of Vesicular Transport Exocytosis Types of Phagocytosis Vesicular Transport Pinocytosis Receptor-mediated endocytosis 26 Which among the types of bulk transport is shown by the process wherein the white blood cells release antibodies as an immune response? 27  Check Your Understanding Identify the terms being described by the following statements. 1. In this process, the plasma membrane balloons inward taking in the molecule. 2. In this process of endocytosis, the cell engulfs the molecule through the use of its extensions then it packs the molecules in a vacuole. 3. This kind of endocytosis forms a vesicle around a liquid molecule. 28  Check Your Understanding Explain how the following macromolecules will enter through the given transport mechanism. 1. Nucleic acids leaving the cell through exocytosis 2. Electrolytes entering the cell through endocytosis 3. A pathogen recognized by white blood cells through phagocytosis 29  Let’s Sum It Up! Larger molecules that cannot be carried through transport proteins can be transported into and out of the cell through bulk or vesicular transport. Molecules that can be transported through the process of bulk transport include proteins, polysaccharides, and nucleic acids. 30  Let’s Sum It Up! There are different processes involved in bulk transport which are budding, scission, uncoating, translocation, tethering and fusion. Exocytosis is a process of transporting molecules outside the cell while endocytosis is transporting the molecules into the cell. 31  Let’s Sum It Up! The two kinds of endocytosis are phagocytosis and pinocytosis. ○ Phagocytosis is a process of endocytosis in which the cell engulfs the molecules. ○ In pinocytosis, the vesicles form around a liquid. 32  Let’s Sum It Up! A special form of pinocytosis is known as receptor-mediated endocytosis which enables the cell to acquire solutes through the coated pit that pinches to form a vesicle. 33 Let’s Sum It Up! General mechanism of bulk or vesicular transport 34 Challenge Yourself Neurotransmitters are stored inside small sacs called synaptic vesicles which are released into the synaptic cleft of the synapse. These are used to communicate with each other at junctions known as chemical synapses. What type of bulk transport is being used in the situation? Justify your answer. 35  Photo Credit Bibliography Hoefnagels, Marielle. Biology: The Essentials. 2nd ed. McGraw-Hill Education, 2016. Mader, Sylvia S., and Michael Windelspecht. Biology. 11th ed. McGraw-Hill Education, 2014. Slide 10: Golgi apparatus_ borderless version)- en.svg by Kelvinsong, is licensed under CC BY 3.0 Reece, Jane B, Martha R. Taylor, Eric J. Simon, Jean L. Dickey, via Wikimedia Commons. and Kelly Hogan. Biology Concepts and Connections. 8th ed. Pearson Education South Asia Pte Ltd., 2016. Simon, Eric J., and Jane B. Reece. Campbell Essential Biology. 5th ed. Pearson Education Inc., 2013. Starr, Cecie, Christine A. Evers, and Lisa Starr. Biology Today and Tomorrow. 4th ed. Cengage Learning Asia Pte Ltd, 2014. 36