Bio Final 2020 Exam Paper PDF

## Exams **25. A student discovers a mutated Akt protein such that the kinase is always active. Which of the following would increase?** - Phosphorylation of the Bad protein - Degradation of a Bcl-2 protein **5. The activation of many protein kinases in signal transduction pathway is an example o...

## Exams **25. A student discovers a mutated Akt protein such that the kinase is always active. Which of the following would increase?** - Phosphorylation of the Bad protein - Degradation of a Bcl-2 protein **5. The activation of many protein kinases in signal transduction pathway is an example of which of the following?** - Amplification **9. What is the basic effect of the cholera toxin on G protein?** - Signal amplification **70. Which of the following is NOT involved in protein phosphorylation?** - Regulation of transcription factors **69. Which of the following statements is NOT true regarding mTOR kinase?** - mTOR is a thyrosine kinase **68. What is the target for ubiquitylation by the active anaphase-promoting complex (APC)?** - Securin **67. Which of the following binds receptor phosphotyrosine residues via its SH2 domain?** - P13 Kinase **59. What is an ubiquitin protein?** - Protein that tags another protein for proteolysis **57. Consider a signaling protein that is only made up of one SH2 domain and two SH3 domains. This protein is most likely which of the following?** - An adaptor protein **56. How do mammalian cells respond to a go-ahead signal?** - Complete the cycle and divide **55. Which of the following is released by platelets in the vicinity of an injury?** - PDGF **53. Which of the following is TRUE regarding cyclin?** - Decreases when MPF activity increases **52. In yeast signal transduction, the yeast cells** - Produce signal molecules that can interact with one another **51. When a neuron responds to a particular neurotransmitter, the neurotransmitter is serving as which part of the signal pathway?** - Signal molecule **50. The decline of MPF activity at the end of mitosis is due to which of the following?** - Degradation of cyclin **40. What is determined by the spindle check point?** - Chromosomes attachment to the metaphase plate **39. Which of the following statements is FALSE about the activation of insulin receptor?** - Activation of Ras/MAP kinase pathway **37. Which amino acids are known to be phosphorylated by protein kinases?** - Serine, threonine, tyrosine **36. During what part of the signal transduction pathway is Ras activated?** - Early in the pathway **35. In the early stages of cell cycle, progression from one phase to the next is controlled by which of the following complexes?** - Cyclin-CDK **33. What is the function of phosphatases in signal transduction processes?** - Inactivate protein kinases and turn off the signal transduction **32. Which of the following events is a mechanism for terminating signal transduction by GPCRs?** - Activation of the phosphodiesterase **19. Which of the following best describe the paracrine signaling?** - Growth factors that control cell proliferation in a healing wound function - Cytokines that cause an inflammatory response in the infection area - Signaling molecules released by one cell act on neighboring target cells **18. Why are kinases and phosphatases essential for the cell?** - Help turn proteins "on and off" **17. What event is responsible for terminating signal transduction by RTKs?** - Receptor internalization **16. Cyclin-dependent kinases (Cdks) activate target proteins by which of the following processes?** - Changing the shape and function of the target proteins