Basal Ganglia PDF د.طه بوتج 2024

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IngeniousRhinoceros3773

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TD Medical College

2024

د.طه بوتج

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anatomy neuroscience basal ganglia brain

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This document is a set of notes on the basal ganglia, a collection of masses of gray matter within each cerebral hemisphere, including their components, groupings and functions. This document also provides clinical notes and information about disorders of the basal ganglia.

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Basal Ganglia The term basal nuclei is applied to a collection of masses of gray matter situated within each cerebral hemisphere. They are the corpus striatum, the amygdaloid nucleus, and the claustrum. Clinicians and neuroscientists use a variety of different ter...

Basal Ganglia The term basal nuclei is applied to a collection of masses of gray matter situated within each cerebral hemisphere. They are the corpus striatum, the amygdaloid nucleus, and the claustrum. Clinicians and neuroscientists use a variety of different terminologies to describe the basal nuclei. The subthalamic nuclei, the substantia nigra, and the red nucleus are functionally closely related to the basal nuclei, but they should not be included with them. The interconnections of the basal nuclei are complex, but in this account, only the more important pathways are considered. The basal nuclei play an important role in the control of posture and voluntary movement. A. Components 1. Caudate nucleus 2. Putamen 3. Globus pallidus 4. Amygdala (amygdaloid nuclear complex) 5. Claustrum is located between the putamen and the insular cortex and between the external capsule and the extreme capsule. B. Groupings of the basal ganglia 1. Striatum (neostriatum)  Consists of the caudate nucleus and the putamen, which are similar in structure and connections and have a common embryologic origin. 2. Lentiform nucleus  Consists of the putamen and the globus pallidus. 3. Corpus striatum  Consists of the lentiform nucleus and the caudate nucleus. Corpus Striatum The corpus striatum (Figure 1) is situated lateral to the thalamus and is almost completely divided by a band of nerve fibers, the internal capsule, into the caudate nucleus and the lentiform nucleus. The term striatum is used here because of the striated appearance produced by the strands of gray matter passing through the internal capsule and connecting the caudate nucleus to the putamen of the lentiform nucleus. It is an important extrapyramidal center. Caudate Nucleus The caudate nucleus is a large C-shaped mass of gray matter that is closely related to the lateral ventricle and lies lateral to the thalamus (Figure 1). The lateral surface of the nucleus is related to the internal capsule, which separates it from the lentiform nucleus(Figure 2). For purposes of description, it can be divided into a head, a body, and a tail. The head of the caudate nucleus is large and rounded and forms the lateral wall of the anterior horn of the lateral ventricle (Figure 2). The head is continuous inferiorly with the putamen of the lentiform nucleus (the caudate nucleus and the putamen are sometimes referred to as the neostriatum or striatum). Just superior to this point of union, strands of gray matter pass through the internal capsule, giving the region a striated appearance, hence the term corpus striatum. The body of the caudate nucleus is long and narrow and is continuous with the head in the region of the interventricular foramen. The body of the caudate nucleus forms part of the floor of the body of the lateral ventricle. The tail of the caudate nucleus is long and slender and is continuous with the body in the region of the posterior end of the thalamus. It follows the contour of the lateral ventricle and continues forward in the roof of the inferior horn of the lateral ventricle. It terminates anteriorly in the amygdaloid nucleus (Fig 1). 1 Figure 1 Figure 2 Lentiform Nucleus The lentiform nucleus is a wedge-shaped mass of gray matter whose broad convex base is directed laterally and whose blade is directed medially (Fig. 2). It is buried deep in the white matter of the cerebral hemisphere and is related medially to the internal capsule, which separates it from the caudate nucleus and the thalamus. The lentiform nucleus is related laterally to a thin sheet of white matter, the external capsule (Fig.2),which separates it from a thin sheet of gray matter, called the claustrum. 2 The claustrum, in turn, separates the external capsule from the subcortical white matter of the insula. A vertical plate of white matter divides the nucleus into a larger, darker lateral portion, the putamen, and an inner lighter portion, the globus pallidus (Fig.2). The paleness of the globus pallidus is due to the presence of a high concentration of myelinated nerve fibers. Inferiorly at its anterior end, the putamen is continuous with the head of the caudate nucleus (Fig.1). AMYGDALOID NUCLEUS The amygdaloid nucleus is situated in the temporal lobe close to the uncus (Fig.1). The amygdaloid nucleus is considered to be part of the limbic system. Through its connections, it can influence the body’s response to environmental changes. In the sense of fear, for example, it can change the heart rate, blood pressure, skin color, and rate of respiration. SUBSTANTIA NIGRA AND SUBTHALAMIC NUCLEI The substantia nigra of the midbrain and the subthalamic nuclei of the diencephalon are functionally closely related to the activities of the basal nuclei and are described elsewhere. The neurons of the substantia nigra are dopaminergic and inhibitory and have many connections to the corpus striatum. The neurons of the subthalamic nuclei are glutaminergic and excitatory and have many connections to the globus pallidus and substantia nigra (Fig.3+4). CLAUSTRUM The claustrum is a thin sheet of gray matter that is separated from the lateral surface of the lentiform nucleus by the external capsule (Fig.2). Lateral to the claustrum is the subcortical white matter of the insula. The function of the claustrum is unknown. Figure 3 3 Figure 4 CONNECTIONS OF THE CORPUS STRIATUM AND GLOBUS PALLIDUS The caudate nucleus and the putamen form the main sites for receiving input to the basal nuclei. The globus pallidus forms the major site from which the output leaves the basal nuclei. They receive no direct input from or output to the spinal cord. CONNECTIONS OF THE CORPUS STRIATUM ► Afferent Fibers  Corticostriate Fibers  All parts of the cerebral cortex send axons to the caudate nucleus and the putamen.  Each part of the cerebral cortex projects to a specific part of the caudate putamen complex.  Most of the projections are from the cortex of the same side.  The largest input is from the sensory motor cortex.  Glutamate is the neurotransmitter of the corticostriate fibers (Fig.6).  Thalamostriate Fibers  The intralaminar nuclei of the thalamus send large numbers of axons to the caudate nucleus and the putamen (Fig.5).  Nigrostriate Fibers  Neurons in the substantia nigra send axons to the caudate nucleus and the putamen (Figs.5 and 6) and liberate dopamine at their terminals as the neurotransmitter.  It is believed that these fibers are inhibitory in function.  Brainstem Striatal Fibers  Ascending fibers from the brainstem end in the caudate nucleus and putamen (Figs.5 and 6) and liberate serotonin at their terminals as the neurotransmitter.  It is thought that these fibers are inhibitory in function. 4 ► Efferent Fibers  Striatopallidal Fibers  Striatopallidal fibers pass from the caudate nucleus and putamen to the globus pallidus (Fig.5).  They have gamma-aminobutyric acid (GABA) as their neurotransmitter (Fig.6).  Striatonigral Fibers  Striatonigral fibers pass from the caudate nucleus and putamen to the substantia nigra (Fig.5).  Some of the fibers use GABA or acetylcholine as the neurotransmitter, while others use substance P (Fig.6). CONNECTIONS OF THE GLOBUS PALLIDUS ► Afferent Fibers  Striatopallidal Fibers  Striatopallidal fibers pass from the caudate nucleus and putamen to the globus pallidus.  As noted previously, these fibers have GABA as their neurotransmitter (Fig.6). ► Efferent Fibers  Pallidofugal Fibers  Pallidofugal fibers are complicated and can be divided into groups: 1. the ansa lenticularis, which pass to the thalamic nuclei; 2. the fasciculus lenticularis, which pass to the subthalamus; 3. the pallidotegmental fibers, which terminate in the caudal tegmentum of the midbrain; and 4. the pallidosubthalamic fibers, which pass to the subthalamic nuclei. Figure 5 5 Figure 6 Figure 7 6 FUNCTIONS OF THE BASAL NUCLEI The basal nuclei (Fig.7) are joined together and connected with many different regions of the nervous system by a very complex number of neurons. Basically, the corpus striatum receives afferent information from most of the cerebral cortex, the thalamus, the subthalamus, and the brainstem, including the substantia nigra. The information is integrated within the corpus striatum, and the outflow passes back to the areas listed above. This circular pathway is believed to function as follows. The activity of the basal nuclei is initiated by information received from the premotor and supplemental areas of the motor cortex, the primary sensory cortex, the thalamus, and the brainstem. The outflow from the basal nuclei is channeled through the globus pallidus, which then influences the activities of the motor areas of the cerebral cortex or other motor centers in the brainstem. Thus, the basal nuclei control muscular movements by influencing the cerebral cortex and have no direct control through descending pathways to the brainstem and spinal cord. In this way, the basal nuclei assist in the regulation of voluntary movement and the learning of motor skills. Writing the letters of the alphabet, drawing a diagram, passing a football, using the vocal cords in talking and singing, and using the eye muscles when looking at an object are a few examples where the basal nuclei influence the skilled cortical motor activities. Destruction of the primary motor cerebral cortex prevents the individual from performing fine discrete movements of the hands and feet on the opposite side of the body. However, the individual is still capable of performing gross crude movements of the opposite limbs. If destruction of the corpus striatum then takes place, paralysis of the remaining movements of the opposite side of the body occurs. The basal nuclei not only influence the execution of a particular movement of, say, the limbs but also help prepare for the movements. This may be achieved by controlling the axial and girdle movements of the body and the positioning of the proximal parts of the limbs. The activity in certain neurons of the globus pallidus increases before active movements take place in the distal limb muscles. This important preparatory function enables the trunk and limbs to be placed in appropriate positions before the primary motor part of the cerebral cortex activates discrete movements in the hands and feet. Clinical Notes  Disorders of the basal nuclei are of two general types. o Hyperkinetic disorders are those in which there are excessive and abnormal movements, such as seen with chorea, athetosis, and ballism. o Hypokinetic disorders include those in which there is a lack or slowness of movement.  Parkinson disease includes both types of motor disturbances. CHOREA In chorea, the patient exhibits involuntary, quick, jerky, irregular movements that are nonrepetitive. Swift grimaces and sudden movements of the head or limbs are good examples. Huntington Disease an autosomal dominant inherited disease, with the onset occurring most often in adult life. Death occurs 15 to 20 years after onset. The disease has been traced to a single gene defect on chromosome 4. This gene encodes a protein, huntingtin, the function of which is not known. The codon (CAG) that encodes glutamine is repeated many more times than normal. The disease affects men and women with equal frequency and unfortunately often reveals itself only after they have had children. Patients have the following characteristic signs and symptoms: 1. Choreiform movements first appear as involuntary movements of the extremities and twitching of the face (facial grimacing). Later, more muscle groups are involved, so the patient becomes immobile and unable to speak or swallow. 7 2. Progressive dementia occurs with loss of memory and intellectual capacity. In this disease, there is a degeneration of the GABA-secreting, substance P–secreting, and acetylcholine-secreting neurons of the striatonigral-inhibiting pathway. This results in the dopa secreting neurons of the substantia nigra becoming overactive; thus, the nigrostriatal pathway inhibits the caudate nucleus and the putamen (Fig. 10-6). This inhibition produces the abnormal movements seen in this disease. Computed tomography scans show enlarged lateral ventricles due to degeneration of the caudate nuclei. Medical treatment of Huntington chorea has been disappointing. Sydenham Chorea Sydenham chorea (St.Vitus’ dance) is a disease of childhood in which there are rapid, irregular, involuntary movements of the limbs, face, and trunk. The condition is associated with rheumatic fever. The antigens of the streptococcal bacteria are similar in structure to the proteins present in the membranes of striatal neurons. The host’s antibodies not only combine with the bacterial antigens but also attack the membranes of the neurons of the basal ganglia. This results in the production of choreiform movements, which are fortunately transient, and there is full recovery. Hemiballismus Hemiballismus is a form of involuntary movement confined to one side of the body. It usually involves the proximal extremity musculature, and the limb suddenly flies about out of control in all directions. The lesion, which is usually a small stroke, occurs in the opposite subthalamic nucleus or its connections; it is in the subthalamic nucleus that smooth movements of different parts of the body are integrated. Parkinson Disease Parkinson disease is a progressive disease of unknown cause that commences between the ages of 45 and 55 years. It is associated with neuronal degeneration in the substantia nigra and, to a lesser extent, in the globus pallidus, putamen, and caudate nucleus. The disease affects about 1 million people in the United States. The degeneration of the neurons of the substantia nigra that send their axons to the corpus striatum results in a reduction in the release of the neurotransmitter dopamine within the corpus striatum (Figs. 10-7 and 10-8). This leads to hypersensitivity of the dopamine receptors in the postsynaptic neurons in the striatum. Patients have the following characteristic signs and symptoms: 1. Tremor. This is the result of the alternating contraction of agonists and antagonists. The tremor is slow and occurs most obviously when the limbs are at rest. It disappears during sleep. It should be distinguished from the intention tremor seen in cerebellar disease, which only occurs when purposeful active movement is attempted. 2. Rigidity. This differs from the rigidity caused by lesions of the upper motor neurons in that it is present to an equal extent in opposing muscle groups. If the tremor is absent, the rigidity is felt as resistance to passive movement and is sometimes referred to as plastic rigidity. If the tremor is present, the muscle resistance is overcome as a series of jerks, called cogwheel rigidity. 3. Bradykinesis. There is a difficulty in initiating (akinesia) and performing new movements. The movements are slow, the face is expressionless, and the voice is slurred and unmodulated. Swinging of the arms in walking is lost. 4. Postural disturbances. The patient stands with a stoop, and his or her arms are flexed. The patient walks by taking short steps and often is unable to stop. In fact, he or she may break into a shuffling run to maintain balance. 8 5. There is no loss of muscle power and no loss of sensibility. Since the corticospinal tracts are normal, the superficial abdominal reflexes are normal, and there is no Babinski response. The deep tendon reflexes are normal. There are a few types of Parkinson disease for which the cause is known.  Postencephalitic parkinsonism developed following the viral encephalitis outbreak of 1916–17 in which damage occurred to the basal nuclei.  Iatrogenic parkinsonism can be a side effect of antipsychotic drugs (e.g., phenothiazines). Meperidine analogues (used by drug addicts) and poisoning from carbon monoxide and manganese can also produce the symptoms of parkinsonism.  Atherosclerotic parkinsonism can occur in elderly hypertensive patients. Parkinson disease may be treated by elevating the brain dopamine level. Unfortunately, dopamine cannot cross the blood-brain barrier, but its immediate precursor L-dopa can and is used in its place. 1. L-Dopa is taken up by the dopaminergic neurons in the basal nuclei and converted to dopamine. 2. Selegiline, a drug that inhibits monoamine oxidase, which is responsible for destroying dopamine, is also of benefit in the treatment of the disease. There is evidence that selegiline can slow the process of degeneration of the dopa-secreting neurons in the substantia nigra. Since most of the symptoms of Parkinson disease are caused by an increased inhibitory output from the basal nuclei to the thalamus and the precentral motor cortex, surgical lesions in the globus pallidus (pallidotomy) have been shown to be effective in alleviating parkinsonian signs. At the present time, such procedures are restricted to patients who are no longer responding to medical treatment. Drug-Induced Parkinsonism  Although Parkinson disease (primary parkinsonism) is the most common type of parkinsonism found in clinical practice, drug induced parkinsonism is becoming very prevalent.  Drugs that block striatal dopamine receptors (D2) are often given for psychotic behavior (e.g., phenothiazines and butyrophenones).  Other drugs may deplete striatal dopamine (e.g., tetrabenazines). Drug-induced parkinsonism disappears once the agent is withdrawn. Athetosis Athetosis consists of slow, sinuous, writhing movements that most commonly involve the distal segments of the limbs. Degeneration of the globus pallidus occurs with a breakdown of the circuitry involving the basal nuclei and the cerebral cortex. 9

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