AOM - PPH Clinical Practice Guideline PDF
Document Details
Uploaded by LowCostReasoning
null
2024
Tags
Related
- Postpartum Infections & Hemorrhage Study Guide PDF
- Obstetrical Hemorrhage PDF - Level III Module 9
- MOD3-OB2-T7-Abnormalities of the Third Stage of Labor and Postpartum Hemorrhage and Other Disorders of the Puerperium PDF
- Postpartum Hemorrhage (PPH) - 5+ Obs. Shock + Emergencies - PDF
- ELO A: Postpartum Complications After Birth PDF
- Postpartum Hemorrhage (PPH) Lecture Notes PDF
Summary
This document is a clinical practice guideline on postpartum hemorrhage (PPH) from the Association of Ontario Midwives (AOM). It summarizes key aspects of PPH, including definitions, incidence, risk factors, and management approaches. The guideline emphasizes the importance of recognizing systemic racism and equitable care for racialized clients.
Full Transcript
Summary Document POSTPARTUM HEMORRHAGE: AN AOM CLINICAL PRACTICE GUIDELINE This summary provides easy access to some of the most essential content of AOM CPG No. 17 – Postpartum Hemorrhage, and it is intended for use in conjunction with the full-length CPG. For a complete analysi...
Summary Document POSTPARTUM HEMORRHAGE: AN AOM CLINICAL PRACTICE GUIDELINE This summary provides easy access to some of the most essential content of AOM CPG No. 17 – Postpartum Hemorrhage, and it is intended for use in conjunction with the full-length CPG. For a complete analysis of the research relevant to the midwife’s management of atonic postpartum hemorrhage (PPH), along with all citations, refer to the full CPG. DEFINITION OF PPH PPH has historically been defined as blood loss ≥ 500 mL following vaginal birth and ≥ 1000 mL following caesarean birth. Using a higher threshold to define PPH may reduce the tendency to categorize blood loss that is higher than these standard thresholds but does not lead to signs and symptoms of hypovolemic shock, as hemorrhage. This could result in less pathologization of normal blood loss and reduce unnecessary intervention. Clinically, any amount of blood loss that results in signs and symptoms of hypovolemic shock or hemodynamic instability should be considered PPH. (1) Good Practice Statement: 1. Midwives should consider a postpartum hemorrhage to be: Postpartum blood loss ≥ 1000 mL; Any postpartum blood loss that causes signs and symptoms of hypovolemic shock or hemodynamic instability. [new 2024] Good practice statement This good practice statement recognizes that blood loss and its physiologic consequences vary across individuals. Midwives use various clinical indicators and account for community standards and hospital protocols to guide timely decision-making. They are skilled at responding to emergency situations in all birthplace settings. INCIDENCE OF PPH Primary PPH is estimated to occur in 2% to 6% of all births worldwide. (18,19) Between 2020 and 2022, the rate of PPH was 3% in Ontario. (2) In Janssen et al.’s study of outcomes of births attended by midwives in British Columbia, PPH occurred in 3.8% of planned home births and 6% of planned hospital births. (3) In Hutton et al.’s study of Ontario midwifery births, PPH was documented in 2.5% of home births and 3.0% of hospital births. (4) CAUSES AND COMPLICATIONS OF PPH The pathophysiology of PPH can be conceptualized by the Four Ts: tone, tissue, trauma and thrombin. Birthing parent deaths and severe adverse outcomes due to PPH are rare. (5,6) Potential complications of PPH include organ dysfunction, coagulopathy, sepsis and pituitary infarction (Sheehan’s syndrome). (1,7,8) Less severe clinical outcomes include iron deficiency anemia, fatigue and delayed lactogenesis. (9,10) RISK FACTORS ASSOCIATED WITH PPH Most factors are not strongly predictive of PPH, which often occurs in the absence of risk factors. It is unclear how multiple risk factors affect overall risk of PPH. Black birthing parents experience inequitable rates of PPH, higher risks of severe morbidity and inequities in levels of care. (11–13) Though many researchers incorrectly attribute inequities to biological differences, midwives should recognize systemic racism as a root cause of harm. In addition to the factors presented in the table below, anemia, assisted reproductive therapy, induction or augmentation of labour and duration of labour also increase the risk of PPH. SELECTED RISK FACTORS FOR ATONIC POSTPARTUM HEMORRHAGE Stronger risk factors Moderate risk factors Weaker risk factors Known before birth Placenta previa Multifetal gestation BMI ≥ 30 kg/m2 Uterine fibroids Age < 20 Chorioamnionitis SSRI exposure Previous PPH 32-36 weeks’ GA Hypertensive disorders of pregnancy Polyhydramnios Parity > 5 Parity = 0 Previous CS Age ≥ 40 Known after birth CS with labour Birthweight > 4500 g CS Instrumental delivery (forceps or vacuum) CS without labour Good Practice Statement: 2. Midwives should recognize and address systemic racism and colonialism as causes of inequitable PPH outcomes for racialized clients. Midwives should engage in ongoing self-reflection, provide equitable access and advocacy, and support racially concordant client care. [new 2024] Good practice statement This good practice statement recognizes that racism, not biological difference, impacts inequitable rates of PPH for racialized clients. Acknowledging and addressing one’s own implicit biases, as well as structural racism embedded in the health-care system, works toward closing gaps in the quality and safety of care for Indigenous, Black and racialized clients, and other equity-denied birthing communities. 2: Postpartum Hemorrhage Summary Document Good Practice Statement: 3. Identification of risk factors for PPH should occur in an ongoing manner throughout the course of antenatal and intrapartum care. Midwives should consider their clients’ risk factors, preferences, values and risk tolerance, in informed choice discussions about options for management of the third stage of labour and choice of birthplace. Good practice statement This good practice statement recognizes continuity of care and midwives’ abilities to identify emerging risk factors for PPH, as well as the client as the primary decision-maker. APPROACHES TO MANAGEMENT OF THE THIRD STAGE DEFINING THIRD-STAGE MANAGEMENT APPROACHES Expectant management Expectant third-stage management has been characterized as a hands-off approach: A uterotonic agent is not administered prophylactically; Placental separation is awaited without intervention; Cord clamping is delayed; The placenta is born spontaneously through birthing parent effort or gravity alone. Physiologic management Physiologic management encompasses many of the same components as expectant management (e.g., absence of uterotonic, no controlled cord traction, delivery of optimal cord clamping). However, it also includes actions to promote the physiologic processes of the third stage, stimulating parasympathetic processes and producing a cascade of hormones that stimulate the endogenous physiologic processes of the third stage of labour. (14–16) The following factors are often included: Facilitating a comfortable, warm environment; Encouraging an upright position to facilitate birth of placenta; Refraining from fundal massage; Occasionally “lifting” or “easing” the cord to bring out the placenta once separation has occurred; Facilitating immediate skin-to-skin contact with the newborn and early chest/breastfeeding. Active management Historically, an active management package included the administration of uterotonic agents, controlled cord traction (CCT) and uterine massage after delivery of the placenta as ways to prevent PPH. Today active management is increasingly defined as the use of a prophylactic uterotonic alone (8,83). No guideline groups recommend uterine massage. THIRD-STAGE MANAGEMENT: ACTIVE VS. EXPECTANT Results from meta-analyses of four RCTs (n = 4829) show that when compared with expectant management, active management probably reduces blood loss ≥ 500 mL, blood transfusion and use of therapeutic uterotonics, while likely increasing afterpains for low-risk participants. It may also increase postnatal vomiting and return to hospital for this population. (19) For participants at both low and high risk of PPH, the findings are similar, although the evidence suggests that active management may also reduce rates of blood loss ≥ 1000 mL. Results from these studies should be interpreted with caution due to their design, implementation and limited applicability to Ontario midwifery. In these studies, active management packages included uterotonics that are no longer in routine use; early cord clamping, which is no longer recommended; and CCT. Expectant management packages do not reflect actions taken by midwives when active management is not chosen. 3: Postpartum Hemorrhage Summary Document THIRD-STAGE MANAGEMENT: ACTIVE VS. PHYSIOLOGIC Results from three large observational studies (n = 53 398) show that optimal physiologic management by midwives may be more effective at reducing rates of blood loss ≥ 500 mL and ≥ 1000 mL, compared with active management. (16, 20, 54) THIRD-STAGE MANAGEMENT: ADDITIONAL CONSIDERATIONS Cultural safety: It is critical that cultural ceremonies be honoured, and that midwives provide culturally safe care to support and advocate for Indigenous clients in all health-care settings. Choice of birthplace: In all birth settings, research shows that active management is associated with an increased risk of blood loss ≥ 1000 mL compared with physiologic management. (20) Delayed cord clamping: This method has become the standard of care across Ontario, regardless of third-stage management approach, due to its substantive benefits. Chest/breastfeeding and skin-to-skin contact: Chest/breastfeeding and skin-to-skin contact can stimulate the release of oxytocin, which can help with uterine contraction, thus potentially reducing the risk of PPH. Herbal and homeopathic remedies: Midwives who support clients in the use of natural health products must have the appropriate knowledge, skills and judgment to do so. Recommendations and Good Practice Statement: 4. Midwives should discuss the risks and benefits of physiologic management and active management with clients as part of an informed choice discussion. This discussion should address: How risk factors, if present, may increase a client’s risk of PPH and impact considerations about choice of birthplace; The client’s preferences, values and risk tolerance; The client’s cultural practices associated with the third stage. This discussion, including the client’s choice, should be appropriately documented. Strong recommendation: low certainty of evidence This recommendation recognizes multiple reasonable approaches to third-stage management, including evidence that supports physiologic management by midwives. It also recognizes that the presence of one or more risk factors is not necessarily predictive of PPH, and that the client is the primary decision-maker. 5. Regardless of the third-stage management approach chosen, midwives should: Offer delayed cord clamping; Encourage immediate skin-to-skin contact, early chest/breastfeeding and other measures that may encourage the release and uptake of oxytocin; Support the client’s cultural practices and preferences associated with the third stage; Await signs of placental separation and monitor for excessive blood loss. [new 2024] Good practice statement This good practice statement recognizes the benefits of delayed cord clamping and physiologic processes that encourage the release and uptake of oxytocin. It also recognizes midwives’ ability to assess and monitor clients for signs of PPH and respond to emergency situations as they emerge. 6. When physiologic management is chosen, midwives should: Await signs of placental separation; Allow the placenta to be born spontaneously with birthing parent effort or gravity; Consider guiding out the placenta after separation; Support other hormonal, psychological and physiologic processes that encourage endogenous oxytocin production, such as maintaining a calm, warm environment and upright positioning. Strong recommendation: low certainty of evidence This recommendation supports physiologic birth, recognizing observational literature that demonstrates the benefits of physiologic management packages provided by midwives. 4: Postpartum Hemorrhage Summary Document COMPONENTS OF THE ACTIVE MANAGEMENT PACKAGE TYPE OF UTEROTONIC Results from a network meta-analysis that included 196 RCTs (n = 135 559) demonstrate that oxytocin is more effective than misoprostol, injectable prostaglandins or ergometrine, with fewer side effects for active management of the third stage in vaginal births. (21) Carbetocin appears to be similar in efficacy to oxytocin, if not more effective for individuals who have vaginal births. However, its effect on blood loss ≥ 1000 mL and hypertension is unclear, and further research is required. Route of administration Systematic review evidence shows that IV oxytocin reduces the rate of blood transfusion and the risk of blood loss ≥ 500 mL, and it probably reduces rates of blood loss ≥ 1000 mL and serious birthing parent morbidity compared with IM administration. (22) It may also reduce the need for additional uterotonics. Though research suggests that IV administration may be more effective for the prevention of PPH, both IV and IM administration of oxytocin are reasonable options. Timing of administration One small RCT (n = 600) found that there may be little to no difference in the risk of blood loss ≥ 600 mL when oxytocin is administered either one minute after delivery of anterior shoulder or after birth. (23) Waiting until after birth to administer a prophylactic uterotonic in clients without prenatal ultrasounds reduces the risk of theoretically entrapping an undiagnosed twin. (24) Controlled cord traction A meta-analysis of four RCTs found that CCT, as part of active management, slightly reduces the risk of blood loss ≥ 500 mL, and it reduces rates of manual removal of the placenta and levels of pain. (25,26) Effective counterpressure is critical to avoid uterine prolapse and/or inversion. (27) Recommendation: 7. When active management is chosen for the prevention of PPH, midwives should: Use oxytocin as the uterotonic (IV or IM); Consider carbetocin, where available, as a reasonable alternative to oxytocin; Consider CCT, while guarding the uterus, after the placenta has separated. [new 2024] Strong recommendation: moderate certainty of evidence This recommendation recognizes a large body of research in support of oxytocin as an effective strategy to prevent blood loss with minimal side effects compared with other uterotonics. It also recognizes the small body of evidence supporting the use of CCT as part of an active management package. ADJUNCTS TO OXYTOCIN Uterotonics Concurrent administration of misoprostol plus oxytocin and ergometrine plus oxytocin may both result in fewer cases of blood loss ≥ 500 mL compared with prophylactic use of oxytocin alone. However, these combinations also have significant side effects, including vomiting and fever. Ergometrine is vasoconstrictive and may increase the risk of retained placenta. (15,28) Tranexamic acid Systematic review evidence found simultaneous administration of TXA with oxytocin prophylactically reduces the need for blood transfusions and additional uterotonics, and it probably reduces rates of blood loss ≥ 500 mL and ≥ 1000 mL compared with oxytocin with placebo or no treatment. TXA increases rates of nausea or vomiting, but it likely does not increase thromboembolic events. 5: Postpartum Hemorrhage Summary Document Recommendation: 8. Midwives may consider concurrent administration of an additional uterotonic with oxytocin for active management of the third stage of labour, according to the clinical picture. [new 2024] Weak recommendation: low certainty of evidence This recommendation recognizes that midwives use knowledge, skills and judgment to determine if adjuncts are required, alongside a consideration of risks and benefits, client risk factors, client preferences and values and birthplace setting. Uterine massage Three RCTs found that routine use of uterine massage in an active management package may make little to no difference to blood loss, use of additional uterotonics, blood transfusion or other hemostatic procedures. (29–31) However, one-third of participants reported pain or discomfort with uterine massage. Recommendation: 9. Uterine massage is not recommended as a routine component of active management of the third stage. Strong recommendation: low certainty of evidence This recommendation recognizes that the available research does not support the routine use of uterine massage after prophylactic oxytocin has been administered, as it introduces potential harm to clients with no clear benefit. There is no evidence available on the use of routine uterine massage where no prophylactic uterotonic has been administered. ASSESSING UTERINE TONE AND BLOOD LOSS FUNDAL TONE ASSESSMENT After delivery of the placenta, fundal checks allow for confirmation of uterine tone. No studies were found on their effectiveness, despite routine use. (13) Summary statement undal tone assessment is an important part of how midwives assess uterine atony and monitor for possible complications. F Fundal tone assessments do not include routine rubbing or massaging of the uterus and should be conducted with minimal disruption of the parent-infant dyad. MEASUREMENT OF BLOOD LOSS Calibrated drapes One RCT (n = 5561) found that calibrated drapes, compared with visual estimation, may slightly reduce severe morbidity, blood transfusions and use of therapeutic uterotonics, and they may slightly increase rates of manual removal of the placenta. (32) Compared with gravimetric methods, use of calibrated drapes resulted in an increase in reported blood ≥ 500 mL and a reduction in rates of operative procedures and manual removal of the placenta. (32) Gravimetric methods Three retrospective studies showed that visual methods may underestimate blood loss compared with gravimetric methods. They may also result in a longer length of stay (2.6 vs. 3.2 days). (33–35) We are very uncertain of these results. Though visual estimation can be used regardless of birthplace, calibrated drapes and gravimetric methods may not be accessible, practical or preferred by clients in all settings. 6: Postpartum Hemorrhage Summary Document Recommendation: 10. Midwives should routinely estimate blood loss visually. Quantitative methods may be used where feasible. [new 2024] Weak recommendation: low certainty of evidence This recommendation recognizes the limits of the research evidence on methods of blood loss estimation. It also recognizes the limited feasibility of implementing quantitative blood loss measurement outside of hospital settings and settings with limited care providers. PHARMACOLOGICAL TREATMENT OF PPH FIRST-LINE TREATMENT Compared with oxytocin, misoprostol appears to be less effective in first-line treatment of PPH, and it introduces significant side effects. A network meta-analysis of low certainty of evidence found that for every 1000 clients, administration of misoprostol vs. oxytocin may result in 54 more cases of additional blood loss ≥ 500 mL, 26 more cases of additional uterotonic use, 11 more cases of additional blood loss ≥ 1000 mL and 34 more cases of fever. Misoprostol also likely increases the risk of blood transfusion and vomiting. (36) Recommendation: 11. Midwives should use oxytocin as the first-line uterotonic for the treatment of PPH due to uterine atony. Strong recommendation: moderate certainty of evidence This recommendation acknowledges the effectiveness of oxytocin as a first-line treatment. Further research on the efficacy of carbetocin compared with oxytocin is required. ADJUNCTS TO FIRST-LINE TREATMENT Additional uterotonics A network meta-analysis found that misoprostol plus oxytocin is likely more effective than oxytocin alone, resulting in 34 fewer cases of blood loss ≥ 500 mL and four fewer cases of blood loss ≥ 1000 mL per 1000 clients. However, the addition of misoprostol likely increases the number of individuals who experience fever (312 more per 1000) and vomiting (29 more per 1000). With adjuncts, midwives must balance the benefits against the increased risk of side effects. Recommendation: 12. Midwives may consider concurrent administration of an additional uterotonic with oxytocin for the treatment of PPH, considering client risk factors and the clinical picture. [new 2024] Weak recommendation: moderate certainty of evidence This recommendation recognizes the limited evidence on adjuncts, with current evidence demonstrating that the addition of misoprostol may improve some PPH outcomes but with significant side effects. Midwives must balance benefits and harms and consider client preferences, values and risk tolerance. Tranexamic acid A systematic review, including two RCTs (n = 14 363), found that TXA as an adjunct to oxytocin reduces rates of hysterectomy (three fewer per 1000). (37) TXA also probably reduces rates of death due to bleeding, and it may reduce rates of blood transfusion and admission to ICU. 7: Postpartum Hemorrhage Summary Document Recommendation: 13. Midwives may consider TXA as an adjunct PPH treatment, if available. [new 2024] Weak recommendation: low certainty of evidence This recommendation recognizes the literature that suggests that TXA may be a beneficial addition in PPH treatment. TXA is not currently available in all communities. SECOND-LINE TREATMENT There is no consensus on the most effective second-line uterotonic for the treatment of primary PPH due to uterine atony when oxytocin has failed to stop bleeding. Because of this lack of evidence, there is little to guide midwives in balancing the risks and benefits of each uterotonic while considering the client’s specific clinical context. Good practice statement: 14. Available research does not clearly support the use of one particular uterotonic over another for second-line treatment of primary PPH due to uterine atony (ergot alkaloids, prostaglandins or carbetocin). Midwives should choose a second-line uterotonic based on clinical context. Good practice statement This good practice statement recognizes that in the absence of clear evidence, midwives should use their clinical experience, community standards, drug availability and the clinical context of the client and birth to guide second-line uterotonic use. NON-PHARMACOLOGICAL TREATMENT OF PPH UTERINE MASSAGE Uterine massage is suggested in the AOM’s Emergency Skills Workshop Manual as a first step in treatment for atonic PPH, as long as the placenta has been delivered. (3) There is no research on uterine massage for treatment of PPH. Good practice statement: 15. In cases of uterine atony, midwives should consider performing uterine massage to stimulate a contraction following delivery of the placenta. Midwives should expel blood clots when clinically indicated. [new 2024] Good practice statement This good practice statement recognizes midwives’ clinical judgment and skills in managing atonic PPH. EMPTYING THE BLADDER A full bladder may prevent the uterus from contracting effectively; encouraging the client to void or catheterizing the bladder may be helpful. This step is typically undertaken after the administration of first-line treatment and/or uterine massage. Summary statement Emptying the bladder is one common response midwives may use to manage PPH. BIMANUAL COMPRESSION A simulation study found that bimanual compression by one provider could not produce adequate compression of the uterus for more than 150 seconds continuously. (38) A two-person approach reduces provider fatigue and enables effective compression of the uterus for five minutes. (38) Despite limited evidence, bimanual compression is considered a useful and potentially life-saving method to temporarily control acute bleeding that is unresponsive to pharmacological management. 8: Postpartum Hemorrhage Summary Document Recommendation: 16. When bleeding caused by uterine atony is unresponsive to pharmacological treatment methods, midwives should consider bimanual compression as a useful and potentially life-saving method. [new 2024] Strong recommendation: very low certainty of evidence This good practice statement recognizes that bimanual compression (internal or external) is one of a series of actions midwives may take to manage atonic PPH. A two-person approach may be more effective. UTERINE BALLOON TAMPONADE There is a paucity of well-designed, well-controlled studies to examine the effectiveness of UBT on controlling bleeding in high- resource settings. However, evidence from case reports and case series continues to demonstrate its effectiveness in controlling PPH, which is of particular importance for community settings. Systematic review evidence shows the pooled success rate of UBT to be 85.9% (95% CI 83.9-87.9%), and 87% when limited to vaginal deliveries. (39) Results from two non-randomized studies in high- income settings that examined institutional protocols for Bakri UBT found that they may lower rates of surgical intervention and/or death, with relative risks ranging from 0.33 to 0.95 (low certainty of evidence). (40,41) Recommendation: 17. Midwives should consider the use of UBT for atonic PPH that is unresponsive to other treatment methods, and where transport to hospital is necessary or when delays in accessing hospital-based care are anticipated. Weak recommendation: very low certainty of evidence This recommendation recognizes the growing body of literature supporting the use of UBT at all care levels and for all obstetric providers. It acknowledges that midwives attend births in the community and that use of UBT for intractable uterine atony is a potentially life-saving measure. EXTERNAL AORTIC COMPRESSION In the presence of PPH unresponsive to uterotonics and interventions, external aortic compression, whether manual or with a non-pneumatic anti-shock garment (NASG), has been used to reduce blood loss and promote stabilization of the client until further treatment is available. Results from the one RCT found that an NASG, compared with standard care, probably reduces birthing parent mortality and severe birthing parent morbidity and death. Results from the five observational studies show similar results. (42) Recommendation: 18. In the presence of unresponsive PPH, midwives may use external aortic compression to reduce blood loss and promote stabilization of a client until further treatment is available. External aortic compression may include: Manual external aortic compression; The use of an NASG, where available. [new 2024] Weak recommendation: very low certainty of evidence This recommendation acknowledges that midwives attend births in the community and that use of external aortic compression is a potentially life-saving measure for PPH unresponsive to other interventions when transport to hospital is necessary and delays in accessing hospital care are anticipated. 9: Postpartum Hemorrhage Summary Document CLIENTS WHO DECLINE BLOOD PRODUCTS Because individuals vary in their choices regarding use of blood products, and because availability of bloodless alternatives may vary in different communities, a care plan is warranted in the event of severe PPH. (43) Recommendation: 19. For clients who decline blood and blood products, midwives should discuss possible increased risks of morbidity and mortality following severe PPH. Midwives should develop or facilitate a care plan in the event of severe PPH, when blood or blood products would usually be recommended. Good practice statement This good practice statement values the importance of respectful care and interprofessional collaboration to provide client access to options available in the community. RECOVERY AND CARE FOLLOWING PPH BLEEDING IN THE POSTPARTUM PERIOD There is a paucity of research to determine normal postpartum bleeding vs. bleeding patterns that indicate medical intervention. Midwives must use their clinical judgment to determine when follow-up care is needed. Individuals with a history of secondary PPH, vaginal bleeding < 24 weeks’ gestation, third-trimester hospital admission for a variety of reasons, smoking, prolonged or incomplete third stage, or primary PPH ≥ 500 mL may be at increased risk of excessive bleeding in the postpartum period. Good practice statement: 20. Midwives should review with all clients: Typical postpartum blood loss in the immediate postpartum period; How to recognize atypical blood loss and signs and symptoms that may indicate shock or hemodynamic instability; How to contact the midwife and access urgent care when necessary. Good practice statement This good practice statement recognizes the skill of midwives in providing health information to clients and normalizes care provided in the community setting. CHEST/BREASTFEEDING FOLLOWING PPH Four observational studies found that individuals who experienced PPH chest/breastfed for a shorter duration, or were less likely to chest/breastfeed. (9,44–46) PPH ≥ 1500 mL was associated with dyad separation within one hour of birth, and fewer than one-third of babies were in their birthing parent’s arms within one hour of birth, which may have had an impact on chest/breastfeeding. (9) Summary statement actation support, provided by midwives as a standard of care, may be an important part of recovery after PPH for individuals L who plan to chest/breastfeed. IRON DEFICIENCY ANEMIA When PPH occurs, monitoring and treating iron deficiency anemia may improve both hematologic status and clinically relevant outcomes such as fatigue and quality of life for the client. Pooled results from thirteen RCTs found that oral iron compared with IV iron therapy may increase gastrointestinal symptoms and rates of red blood cell transfusions. (47–50) Both treatments may decrease fatigue and depression scores at 12 weeks, with lower scores for those who receive IV iron. (51) Midwives should consider clients 10: Postpartum Hemorrhage Summary Document in their wider social and cultural context. For more information on iron deficiency anemia, see the AOM resource Iron deficiency anemia in the childbearing year. Recommendation: 21. For clients who experience PPH and/or have signs and symptoms of iron deficiency anemia, midwives should recommend oral iron supplementation or IV iron supplementation, as clinically indicated. [new 2024] Strong recommendation: very low certainty of evidence This recommendation recognizes continuity of care and midwives’ ability to effectively assess clients in the postpartum period. It also recognizes client preferences and values, as well as inequitable access to IV iron. CLIENT EXPERIENCES PRACTICE POINTS FOR COMMUNICATION DURING AND FOLLOWING PPH The best practices listed in Figure 1 have the potential to lessen the negative emotional and psychological impacts of PPH. (52–54) FIGURE 1: Practice points for communication during and after PPH Include client and family members or support people in decision-making during an emergency, supporting an informed choice process; Help clients and families understand what is happening; Manage emergency situations in a calm, skilled manner; During PPH Ensure good communication with all involved health-care professionals during the emergency; Ensure that health-care professionals, the client and support people are clear about who will assume the role of most responsible provider (MRP); Provide information to reassure support people if they are waiting anxiously. Provide continuity of care, if possible, during transfers, e.g., midwives riding in the ambulance or starting IVs; Advocate for clients’ emotional and physical needs, e.g., have a private room away from other new families; Facilitate access to baby for clients who require intensive care (or vice versa); Hospital transfer Facilitate regular updates with clients on their baby’s progress if they cannot be with them; Support chest/breastfeeding or milk expression, even if clients are in intensive care; Keep baby skin-to-skin, if possible, during the management of PPH. Offer the client and support people the opportunity to discuss the events of the birth and review the charts and clinical notes. Flexible timing for these meetings is important—some clients may be ready before others; Follow-up Ensure good communication afterwards to help clients make sense of the experience. Advocate for support, if available, from the client’s primary care team after discharge. The ability to debrief and check in is important as clients recover and get Postnatal support back to normal life; Offer or refer clients for counselling to address long-term mental health impacts. 11: Postpartum Hemorrhage Summary Document REFERENCES 1. Leduc D, Senikas V, Lalonde AB, CLINICAL PRACTICE 14];51(4):365–71. Available from: http://www.ncbi.nlm.nih.gov/ OBSTETRICS COMMITTEE. Active management of the pubmed/21806578 third stage of labour: prevention and treatment of postpartum 11. Guan CS, Boyer TM, Darwin KC, Henshaw C, Michos hemorrhage. J Obstet Gynaecol Can [Internet]. 2009 Oct [cited ED, Lawson S, et al. Racial disparities in care escalation for 2013 Apr 7];31(10):980–93. Available from: http://linkinghub. postpartum hemorrhage requiring transfusion. Am J Obstet elsevier.com/retrieve/pii/S0020729209005992 Gynecol MFM. 2023 Jun;5(6):100938. 2. Better Outcomes Registry & Network (BORN) Ontario. 12. Gyamfi-Bannerman C, Srinivas SK, Wright JD, Goffman D, Postpartum hemorrhage among pregnant individuals with a live Siddiq Z, D’Alton ME, et al. Postpartum hemorrhage outcomes or stillbirth. 2023. and race. Am J Obstet Gynecol. 2018 Aug;219(2):185.e1-185.e10. 3. Janssen PA, Saxell L, Page LA, Klein MC, Liston RM, Lee SK. 13. Taylor K, Noel E, Chapple AG, Buzhardt S, Sutton E. Risk factors Outcomes of planned home birth with registered midwife for postpartum hemorrhage in a tertiary hospital in South- versus planned hospital birth with midwife or physician. CMAJ Central Louisiana. The Journal of Maternal-Fetal & Neonatal [Internet]. 2009 Sep 15 [cited 2013 Jun 10];181(6–7):377–83. Medicine. 2024 Mar 6;35(25):7353–9. Available from: http://www.cmaj.ca/content/181/6-7/377.full 14. Hastie C, Fahy KM. Optimising psychophysiology in third stage 4. Hutton EK, Cappelletti A, Reitsma AH, Simioni J, Horne J, of labour: theory applied to practice. Women Birth [Internet]. McGregor C, et al. Outcomes associated with planned place 2009 Sep [cited 2013 Jun 23];22(3):89–96. Available from: http:// of birth among women with low-risk pregnancies. CMAJ www.ncbi.nlm.nih.gov/pubmed/19345629 [Internet]. 2016 Mar 15;188(5):E80-90. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/26696622 15. Begley CM. A comparison of “active” and “physiological” management of the third stage of labour. Midwifery [Internet]. 5. Mehrabadi A, Liu S, Bartholomew S, Hutcheon J a, Kramer MS, 1990 Mar [cited 2013 Jul 28];6(1):3–17. Available from: http:// Liston RM, et al. Temporal trends in postpartum hemorrhage www.ncbi.nlm.nih.gov/pubmed/2182978 and severe postpartum hemorrhage in Canada from 2003 to 2010. J Obstet Gynaecol Can [Internet]. 2014 Jan;36(1):21–33. 16. Fahy K, Hastie C, Bisits A, Marsh C, Smith L, Saxton A. Holistic Available from: http://www.ncbi.nlm.nih.gov/pubmed/24444284 physiological care compared with active management of the third stage of labour for women at low risk of postpartum 6. Joseph KS, Rouleau J, Kramer MS, Young DC, Liston haemorrhage: a cohort study. Women Birth [Internet]. 2010 Dec RM, Baskett TF, et al. Investigation of an increase in [cited 2013 Mar 27];23(4):146–52. Available from: http://www. postpartum haemorrhage in Canada. BJOG [Internet]. 2007 ncbi.nlm.nih.gov/pubmed/20226752 Jun;114(6):751–9. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/17516968 17. Robinson debbie, Basso M, Chan C, Duckitt K, Lett R. Guideline No. 431: Postpartum Hemorrhage and Hemorrhagic 7. Carroli G, Cuesta C, Abalos E, Gulmezoglu a M. Epidemiology Shock. Journal of Obstetrics and Gynaecology Canada. 2022 of postpartum haemorrhage: a systematic review. Best Pract Dec;44(12):1293-1310.e1. Res Clin Obstet Gynaecol [Internet]. 2008 Dec [cited 2013 Mar 24];22(6):999–1012. Available from: http://www.ncbi.nlm.nih. 18. World Health Organization. WHO Recommendations for gov/pubmed/18819848 the Prevention and Treatment of Postpartum Haemorrhage: Evidence base [Internet]. Geneva; 2012. 1–41 p. Available from: 8. World Health Organization. WHO Recommendations for http://www.ncbi.nlm.nih.gov/books/NBK131946/ the Prevention and Treatment of Postpartum Hemorrhage [Internet]. Geneva; 2012 [cited 2014 Jul 30]. Available from: 19. Begley CM, Gyte GM, Devane D, McGuire W, Weeks A, Biesty http://www.ncbi.nlm.nih.gov/pubmed/23586122 LM. Active versus expectant management for women in the third stage of labour. Cochrane Database Syst Rev [Internet]. 9. Thompson JF, Heal LJ, Roberts CL, Ellwood DA. Women’s 2019;2:CD007412. Available from: http://www.ncbi.nlm.nih.gov/ breastfeeding experiences following a significant primary pubmed/30754073 postpartum haemorrhage: A multicentre cohort study. Int Breastfeed J [Internet]. 2010 May 27 [cited 2013 Mar 27];5:5. 20. Davis D, Baddock S, Pairman S, Hunter M, Benn C, Anderson Available from: http://www.pubmedcentral.nih.gov/articlerender. J, et al. Risk of severe postpartum hemorrhage in low-risk fcgi?artid=2889881&tool=pmcentrez&rendertype=abstract childbearing women in new zealand: exploring the effect of place of birth and comparing third stage management of labor. Birth 10. Thompson JF, Roberts CL, Ellwood D a. Emotional and [Internet]. 2012 Jun [cited 2013 Mar 26];39(2):98–105. Available physical health outcomes after significant primary post- from: http://www.ncbi.nlm.nih.gov/pubmed/23281857 partum haemorrhage (PPH): a multicentre cohort study. Aust N Z J Obstet Gynaecol [Internet]. 2011 Aug [cited 2013 Apr 21. Gallos ID, Williams HM, Price MJ, Merriel A, Gee H, Lissauer D, 12: Postpartum Hemorrhage Summary Document et al. Uterotonic agents for preventing postpartum haemorrhage: versus gravimetric measurement of postpartum blood loss: a network meta-analysis. Cochrane Database Syst Rev [Internet]. a prospective cohort study. Arch Gynecol Obstet. 2011 Jun 2018 Apr 25;4(4):CD011689. Available from: http://www.ncbi. 28;283(6):1207–13. nlm.nih.gov/pubmed/29693726 35. Khaleghinezhad K, Dadgar S, Hashempor M, Baharian N, 22. Oladapo OT, Okusanya BO, Abalos E, Gallos ID, Papadopoulou Golmakani N. Comparing the estimation of postpartum A. Intravenous versus intramuscular prophylactic oxytocin hemorrhage using the weighting method and National Guideline for reducing blood loss in the third stage of labour. with the postpartum hemorrhage estimation by midwives. Iran J Cochrane Database of Systematic Reviews [Internet]. Nurs Midwifery Res. 2015;20(4):471. 2020 Nov 10;2020(12). Available from: http://doi.wiley. 36. Parry Smith WR, Papadopoulou A, Thomas E, Tobias A, Price com/10.1002/14651858.CD009332.pub4 MJ, Meher S, et al. Uterotonic agents for first-line treatment of 23. Oguz Orhan E, Dilbaz B, Aksakal SE, Altınbas S, Erkaya S. postpartum haemorrhage: a network meta-analysis. Cochrane Prospective randomized trial of oxytocin administration for Database Syst Rev. 2020 Nov 24;11(11):CD012754. active management of the third stage of labor. Int J Gynaecol 37. Della Corte L, Saccone G, Locci M, Carbone L, Raffone A, Obstet [Internet]. 2014 Nov [cited 2015 Jul 7];127(2):175–9. Giampaolino P, et al. Tranexamic acid for treatment of primary Available from: http://www.ncbi.nlm.nih.gov/pubmed/25108586 postpartum hemorrhage after vaginal delivery: a systematic 24. POPPHI. Prevention of Postpartum Hemorrhage: Implementing review and meta-analysis of randomized controlled trials. J Active Management of the Third Stage of Labor (AMTSL) A Matern Fetal Neonatal Med. 2020 Mar;33(5):869–74. Reference Manual for Health Care Providers. PATH; 2007. 38. Andreatta P, Perosky J, Johnson TRB. Two-provider technique 25. Hofmeyr GJ, Mshweshwe NT, Gülmezoglu AM. Controlled cord for bimanual uterine compression to control postpartum traction for the third stage of labour. Cochrane Database Syst hemorrhage. J Midwifery Womens Health [Internet]. 2012 [cited Rev. 2015 Jan 29;1(1):CD008020. 2013 Aug 7];57(4):371–5. Available from: http://www.ncbi.nlm. nih.gov/pubmed/22758359 26. Hanafi S, El-Shehawy H, Meshmesh K. Impact of controlled cord traction in the management of the third stage of labor on 39. Suarez S, Conde-Agudelo A, Borovac-Pinheiro A, Suarez- postpartum hemorrhage. Evidence Based Womenʼs Health Rebling D, Eckardt M, Theron G, et al. Uterine balloon Journal. 2014 May;4(2):78–81. tamponade for the treatment of postpartum hemorrhage: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020 27. Association of Ontario Midwives. Emergency Skills Workshop Apr;222(4):293.e1-293.e52. Manual. Toronto; 2021. 40. Laas E, Bui C, Popowski T, Mbaku OM, Rozenberg P. Trends 28. Hammar M, Boström K, Borgvall B. Comparison between the in the rate of invasive procedures after the addition of the Influence of Methylergometrine and Oxytocin on the Incidence intrauterine tamponade test to a protocol for management of of Retained Placenta in the Third Stage of Labour. Gynecol severe postpartum hemorrhage. Am J Obstet Gynecol [Internet]. Obstet Invest. 1990;30(2):91–3. 2012 Oct [cited 2013 May 27];207(4):281.e1-7. Available from: 29. Erkaya R, Karabulutlu Ö, Çalik KY. Uterine massage to reduce http://www.ncbi.nlm.nih.gov/pubmed/23021688 blood loss after vaginal delivery. Health Care Women Int. 2021 41. Revert M, Rozenberg P, Cottenet J, Quantin C. Intrauterine Aug 9;1–17. Balloon Tamponade for Severe Postpartum Hemorrhage. 30. Chen M, Chang Q, Duan T, He J, Zhang L, Liu X. Uterine Obstetrics & Gynecology. 2018 Jan;131(1):143–9. Massage to Reduce Blood Loss After Vaginal Delivery. Obstetrics 42. Pileggi-Castro C, Nogueira-Pileggi V, Tunçalp Ö, Oladapo & Gynecology. 2013 Aug;122(2):290–5. OT, Vogel JP, Souza JP. Non-pneumatic anti-shock garment 31. Abdel-Aleem H, Hofmeyr GJ, Shokry M, El-Sonoosy E. Uterine for improving maternal survival following severe postpartum massage and postpartum blood loss. International Journal of haemorrhage: a systematic review. Reprod Health. 2015 Mar Gynecology & Obstetrics. 2006 Jun;93(3):238–9. 31;12:28. 32. Diaz V, Abalos E, Carroli G. Methods for blood loss estimation 43. Tanaka M, Matsuzaki S, Endo M, Kakigano A, Mimura after vaginal birth. Cochrane Database of Systematic Reviews. K, Takiuchi T, et al. Obstetric outcomes and acceptance of 2018 Sep 13;2018(9). alternative therapies to blood transfusion by Jehovah’s Witnesses in Japan: a single-center study. Int J Hematol. 2018 Oct 33. Ayala M, Nookala V, Fogel J, Fatehi M. Visual estimation of 29;108(4):432–7. blood loss versus quantitative blood loss for maternal outcomes related to obstetrical hemorrhage. Baylor University Medical 44. Brown A, Jordan S. Impact of birth complications on Center Proceedings. 2023 May 4;36(3):341–5. breastfeeding duration: an internet survey. J Adv Nurs. 2013 Apr;69(4):828–39. 34. Al Kadri HMF, Al Anazi BK, Tamim HM. Visual estimation 13: Postpartum Hemorrhage Summary Document 45. Drayton BA, Patterson JA, Nippita TA, Ford JB. Red blood cell transfusion after postpartum haemorrhage and breastmilk feeding at discharge: A population‐based study. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2016 Dec 15;56(6):591–8. 46. Chessman J, Patterson J, Nippita T, Drayton B, Ford J. Haemoglobin concentration following postpartum haemorrhage and the association between blood transfusion and breastfeeding: a retrospective cohort study. BMC Res Notes. 2018 Dec 1;11(1):686. 47. Iyoke CA, Emegoakor FC, Ezugwu EC, Lawani LO, Ajah LO, Madu JA, et al. Effect of treatment with single total-dose intravenous iron versus daily oral iron(III)-hydroxide polymaltose on moderate puerperal iron-deficiency anemia. Ther Clin Risk Manag. 2017 May;Volume 13:647–53. 48. Markova V, Norgaard A, Jørgensen KJ, Langhoff-Roos J. Treatment for women with postpartum iron deficiency anaemia. Cochrane Database Syst Rev [Internet]. 2015 Dec 2 [cited 2015 Aug 18];8(12):CD010861. Available from: http://doi.wiley. com/10.1002/14651858.CD010861.pub2 49. Radhika AG, Sharma AK, Perumal V, Sinha A, Sriganesh V, Kulshreshtha V, et al. Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review. The Journal of Obstetrics and Gynecology of India. 2019 Feb 6;69(1):13–24. 50. Sultan P, Bampoe S, Shah R, Guo N, Estes J, Stave C, et al. Oral vs intravenous iron therapy for postpartum anemia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019 Jul;221(1):19-29.e3. 51. Holm C, Thomsen LL, Norgaard A, Langhoff-Roos J. Single-dose intravenous iron infusion or oral iron for treatment of fatigue after postpartum haemorrhage: a randomized controlled trial. Vox Sang. 2017 Apr;112(3):219–28. 52. Association of Ontario Midwives. Midwifery client experiences of postpartum hemorrhage [Internet]. 2015 [cited 2015 Oct 26]. p. 6. Available from: http://www.aom.on.ca/files/Health_Care_ Professionals/Clinical_Practice_Guidelines/WEX_Midwife_ PPH_Resource.pdf 53. Hinton L. Conditions that threaten women’s lives in childbirth & pregnancy | healthtalkonline.org [Internet]. 2013 [cited 2014 Jul 22]. Available from: http://www.healthtalk.org/peoples- experiences/pregnancy-children/conditions-threaten-womens- lives-childbirth-pregnancy/topics 54. Dixon L, Tracy SK, Guilliland K, Fletcher L, Hendry C, Pairman S. Outcomes of physiological and active third stage labour care amongst women in New Zealand. Midwifery [Internet]. 2013 Jan [cited 2013 Jul 14];29(1):67–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22188999 14: Postpartum Hemorrhage Summary Document