Anxiolytic and Hypnotic Drugs Part 3.docx

1\. \*\*Which GABAA receptor subunit do \"Z-drugs\" like zolpidem primarily target?\*\* \- A) Alpha-2 \- B) Alpha-1 \- C) Beta-2 \- D) Gamma-1 \*\*Answer\*\*: B) Alpha-1 2\. \*\*Which \"Z-drug\" is associated with the least daytime sedation?\*\* \- A) Zaleplon \- B) Zolpidem \- C) Eszopiclo...

1\. \*\*Which GABAA receptor subunit do \"Z-drugs\" like zolpidem primarily target?\*\* \- A) Alpha-2 \- B) Alpha-1 \- C) Beta-2 \- D) Gamma-1 \*\*Answer\*\*: B) Alpha-1 2\. \*\*Which \"Z-drug\" is associated with the least daytime sedation?\*\* \- A) Zaleplon \- B) Zolpidem \- C) Eszopiclone \- D) Temazepam \*\*Answer\*\*: A) Zaleplon 3\. \*\*What is the primary therapeutic use of zolpidem?\*\* \- A) Treatment of seizures \- B) Reduction of anxiety \- C) Treatment of insomnia \- D) Muscle relaxation \*\*Answer\*\*: C) Treatment of insomnia 4\. \*\*Which barbiturate is commonly used in the treatment of seizures?\*\* \- A) Amobarbital \- B) Thiopental \- C) Phenobarbital \- D) Secobarbital \*\*Answer\*\*: C) Phenobarbital 5\. \*\*What is the mechanism of action of barbiturates on the GABAA receptor?\*\* \- A) Increase the duration of chloride channel opening \- B) Increase the frequency of chloride channel opening \- C) Block chloride channels \- D) Inhibit sodium channels \*\*Answer\*\*: A) Increase the duration of chloride channel opening 6\. \*\*Why are barbiturates less commonly used for insomnia compared to newer agents like Z-drugs?\*\* \- A) Higher risk of dependence \- B) Shorter half-life \- C) Better safety profile \- D) Less effective in producing sleep \*\*Answer\*\*: A) Higher risk of dependence 7\. \*\*What is the mechanism of action of buspirone?\*\* \- A) Full agonist at the 5-HT1a receptor \- B) Antagonist at the dopamine receptor \- C) Inhibitor of norepinephrine reuptake \- D) GABA agonist \*\*Answer\*\*: A) Full agonist at the 5-HT1a receptor 8\. \*\*What is a major advantage of buspirone over benzodiazepines?\*\* \- A) Faster onset of action \- B) No risk of dependence or withdrawal \- C) Stronger sedative effect \- D) Effective for immediate anxiety relief \*\*Answer\*\*: B) No risk of dependence or withdrawal 9\. \*\*How long does it typically take for buspirone to achieve its full therapeutic effect?\*\* \- A) 1 day \- B) 3 days \- C) 3-4 weeks \- D) 1 week \*\*Answer\*\*: C) 3-4 weeks 10\. \*\*What is the primary mechanism of action of orexin antagonists like suvorexant?\*\* \- A) Inhibition of GABA receptors \- B) Inhibition of orexin A and B signaling \- C) Increase of serotonin levels \- D) Blockade of histamine receptors \*\*Answer\*\*: B) Inhibition of orexin A and B signaling 11\. \*\*What is the most common side effect of suvorexant?\*\* \- A) Respiratory depression \- B) Seizures \- C) Daytime somnolence \- D) Sleep paralysis \*\*Answer\*\*: C) Daytime somnolence 12\. \*\*What condition is suvorexant primarily used to treat?\*\* \- A) Anxiety disorders \- B) Insomnia \- C) Depression \- D) Epilepsy \*\*Answer\*\*: B) Insomnia 13\. \*\*Which first-generation antihistamine is commonly used to treat insomnia?\*\* \- A) Cetirizine \- B) Hydroxyzine \- C) Loratadine \- D) Ranitidine \*\*Answer\*\*: B) Hydroxyzine 14\. \*\*Why are first-generation antihistamines not recommended for chronic treatment of insomnia?\*\* \- A) High risk of dependence \- B) Short duration of action \- C) Poor evidence of efficacy \- D) Increased risk of seizures \*\*Answer\*\*: C) Poor evidence of efficacy 15\. \*\*Which patient population should avoid the use of diphenhydramine for insomnia?\*\* \- A) Pregnant women \- B) Children under 5 \- C) Elderly patients \- D) Patients with asthma \*\*Answer\*\*: C) Elderly patients