Amiodarone PDF

GENERIC NAME amiodarone TRADE, BRAND, OR PROPRIETARY NAME Cordarone® CLASS Antidysrhythmic STANDARD SUPPLY Prefilled syringe MECHANISMS OF ACTION Blocks sodium, potassium, and calcium channels Prolongs the action potential and repolarization Slows the sinus rate Increases the length of the PR interv...

GENERIC NAME amiodarone TRADE, BRAND, OR PROPRIETARY NAME Cordarone® CLASS Antidysrhythmic STANDARD SUPPLY Prefilled syringe MECHANISMS OF ACTION Blocks sodium, potassium, and calcium channels Prolongs the action potential and repolarization Slows the sinus rate Increases the length of the PR interval and QT interval INDICATIONS Ventricular fibrillation Pulseless ventricular tachycardia Wide complex tachycardia CONTRAINDICATIONS Cardiogenic shock Hemodynamically significant bradycardia Second-degree and third-degree heart block Hemodynamically significant hypotension ADVERSE REACTIONS/SIDE EFFECTS Bradycardia Hypotension Heart block Congestive heart failure Headache Dizziness Nausea Vomiting ROUTES OF ADMINISTRATION IV IO Infusion AMIODARONE 1 ONSET OF ACTION 1 to 3 minutes ADULT DOSAGES Cardiac arrest: 300 mg If no response, administer 150 mg over 3 to 5 minutes Tachydysrhythmias: 150 mg in 50 mL D5W infused over 10 minutes Infusion: 1.0 mg/minute PEDIATRIC DOSAGES Ventricular fibrillation: 5.0 mg/kg May repeat the dosage every 5 minutes twice Maximum dosage 300 mg Ventricular tachycardia: 5.0 mg/kg over 20 minutes May repeat the dosage twice SPECIAL CONSIDERATIONS The peak effect of the drug is 10 minutes The duration of the drug is variable AMIODARONE 2