Ageing Disease MCQ PDF

**[MCQ Training Questions for Integrated Pathology ]** 1.**Which ONE of the following diseases is NOT associated with ageing** a. Cancer b. Type 2 diabetes mellitus c. Alzheimer's disease d. Cataract e. **Phenylketonuria** 2. **Which ONE of the following statements is INCORRECT** a. T...

**[MCQ Training Questions for Integrated Pathology ]** 1.**Which ONE of the following diseases is NOT associated with ageing** a. Cancer b. Type 2 diabetes mellitus c. Alzheimer's disease d. Cataract e. **Phenylketonuria** 2. **Which ONE of the following statements is INCORRECT** a. Type 2 diabetes is often characterised by insulin resistance b. Cataract has an increased incidence in the elderly c. **Cancer is a major cause of death in progeria** d. Degeneration of dopamine secreting neurones occurs in Parkinson's disease e. Alzheimer's disease is associated with memory loss 3. **Which ONE of the following is NOT a feature of progeria** a. Thinning of skin b. Prominent scalp veins c. **Tall stature** d. Severe arthritis e. Decreased sexual maturity 4. **Calorie restriction** a. Causes ageing b. Increases advanced glycation endproducts in body tissues c. Reduces lifespan in mammals d. **Reduces advanced glycation endproducts in body tissues** e. Increases free radical activity 5. **Which ONE of the following statements is INCORRECT** a. Calorie restriction reduces age-associated mutations b. Vitamin E is an antioxidant c. Vitamin E is a free radical scavenger d. Life expectancy of progeria is 13 years e. **Alopecia is not a feature of patients with progeria** 6. **A gradual decline in function of cells, organs and tissues with ageing is referred to as** a. Longevity b. Lifespan c. **Senescence** d. Oxidative stress e. Life expectancy 7. **Which ONE of the following statements in INCORRECT** a. Fibroblasts from human embryo's undergo approximately 50 divisions b. Transplanting the nucleus of an old cell into a young cytoplasm will give a new cell with lifespan of the transplanted nucleus c. Transplanting the nucleus of a young cell into an old cytoplasm will give a new cell with the same lifespan as that of the young cell d. **Telomerase cannot prevent shortening of telomeres** e. Liver cells from a strain of mice with a short lifespan have a higher incidence of mutations compared to similar cells from a strain of mice with longer lifespan 8. **Free radicals can damage the following molecules** a. Proteins b. Lipids c. Nucleic acids d. Carbohydrates e. **All of the molecules in this list** **9.Which ONE of the following statements is CORRECT?** a. superoxide radical has a positive charge b. superoxide radical has two lone electrons c. superoxide radical is more reactive than hydroxyl radical d. superoxide radical has same reactivity as hydroxyl radical e. **hydrogen peroxide is not a free radical** **10.Which ONE of the following statements is INCORRECT?** a. glycation refers to the post-translational modification of proteins b. **glucose in the acyclic form does not participate in the glycation reaction** c. extent of protein glycation depends on blood sugar concentration d. only glucose in the acyclic form participates in glycation e. extent of protein glycation can depend on duration of high blood sugar 11. **Telomerase** a. is always switched off in every cell b. can reduce the length of telomeres c. **is switched on in cancer cells** d. is always switched off in haemopoietic cells e. is always switched on in every cell 12. **Which ONE of the following statements is NOT true?** a. lipofuscin accumulation increases in cells with age b. **lipofuscins are usually susceptible to enzymatic digestion** c. lipofuscins are yellow-brown pigments d. lipofuscins may be derived by free radical lipid peroxidation e. lipofuscins are stored in lysosome like structures 13. **Which ONE of the following is the correct definition for lifespan** a. is the maximum age attained by a member of a particular species b. is the mean age of individuals in a population c. is the minimum age of individuals in a population d. is the minimum age attained by a member of a particular species e. is the ability to live forever 14. **Which ONE of the following statements is true?** a. plasma creatinine measurements are not used to assess renal function b. faecal occult blood is used for diagnosis of diabetes c. **calorie restriction increases lifespan in rodents** d. DNA from liver cells of older mice have less mutations e. progeria is the slowing down of ageing 15. **Which ONE of the following statements is INCORRECT?** a. aged cells have abnormal shaped organelles b. lens crystallins become more cross-linked with age c. **skin collagen has increased elasticity with age** d. function of T-lymphocytes decreases with age e. aged liver is less able to detoxify drugs