Pattern Recognition Receptors & Cytokines PDF

Pattern Recognition Receptors & Cytokines ↳ diff specific BCRs &TCRs & their Many PRRs ligands discovered. Focus on TLRS...

Pattern Recognition Receptors & Cytokines ↳ diff specific BCRs &TCRs & their Many PRRs ligands discovered. Focus on TLRS Recognition Pattern Go. * TLRs ↳ (C-term faces cytosol) (Active Domain) Trepeats - - (intracellular) Subcellular Localization of TLRs & Ligands (PAMPs) - 10 diffTLRs , target diff thingsa localized differently · 2 heterodimerizes with 126 (210) extracellular Mendosomal Lintra ). I exposed after opened by phagocytosis  LPS TLR4 : Recognizes · (recognizes Gram () sugar specifically recognizes · auoneno LipidA. sollt TLR associated (dimer) protein resides w/ TLR4 in PM MDL. recognizes sticksin phenylalanine TLR2 : Recognizes Lipoteichoic acids a Lipoproteins from diff bacteria. (5) dimer s jsugar outer surface potein peptide acyl group 3 zacy groups Bind, , speptideBind TLRT speptide) sugar a peptides stabilizea TLR 3/7/8 Endosomal Sensors of Microbial : (Viral) RNAs Cor phagosomall stranded double - to induce dimerization Tendosome ↓ bindinsite for single (most important innate immune cen fighting viral infection as 4 a binding site SSRNA for TLR9 : Endosomal Sensor of microbial DNAs at1end a Cpd at other recognizes cytosine & motif in promoter cunmethylated in bact ) ! (cells activated a their of ThRs genes) Signalling Cascades 0008 - Initiation of signaling transduction, Once activated -> Genes activated : many genes Role of TLRs in adaptive Immunity Viral RNA/DNA Antiviral Immune response Cof antigen (CDSt) Idendritic cells) Y infection (viral , bacterial , etc. ) - Adaptive Immunity cannot decipher WHAT caused an only the innate can tell the origin convey info - to T cells Cytokines "released by ceut releaseenogte released by monocyte picomolar togethe work aether ~ etc. ) All cells can release cytokines (immune epidemal , , Chematopoiesis involved) ↑ (so diff biggest group-diff functions eg macrophage colony. factor (bone marrow stimulating Growth Stimulation) 1. 12-1 family (monokines) 10-1 , 18 36 : , cleaved by other caspasesa I proteases > - bind to receptor not released by themself extracellular to (inflam a + x-helicies , up up down cleared by caspasey. anti-inflam & down , long a short chain on es ↑ cleave closer to N-tem. Class-7 helical 2 Cytokines : 12 2 + 6 12 - , ,. (p35). Class-11 helical 3 cytokines (11-10 22 28/29) , , key Cytokines influencing T cell diff. (Important & antigen, other receptors regulatory Tcell (in follicles (lymphoid) key pro-inflammatory Cytokines induced by leukocytes (12/12 6 12 8) , , , Can go : anneut. vasodilationa further activation key Anti-inflammatory Cytokines IL-1RA 1-2( ? ) +, 10 27 35 37 ,TFB : , , ,. , * Both recombinant 11-2a1L-2 inhibitors cause inflammation ?:. Why Teff & balance * Treg cells time suppressed Anti-inflammon over Maintain homeostasis Ccompromised immune Lissue damage Mecases system