Cell Injury & Necrosis - Medical Notes PDF
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Uploaded by WellPositionedMoldavite1527
Ankara Medipol University
Emrullah Beyazyıldız
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Summary
This document provides a detailed overview of different types of cell death, particularly necrosis. It explains the characteristics and types of necrosis, including coagulation, liquefaction, gangrenous, caseous, and fat necrosis. The document is relevant to medical students or professionals studying cell biology and pathology.
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1-CELL INJURY Necrosis Prof. Dr. Emrullah Beyazyıldız Ankara Medipol University 05057669683 TYPES OF CELL DEATH Necrosis, Apoptosis, Pyroptosis, Necroptosis and Ferroptosis NECRO...
1-CELL INJURY Necrosis Prof. Dr. Emrullah Beyazyıldız Ankara Medipol University 05057669683 TYPES OF CELL DEATH Necrosis, Apoptosis, Pyroptosis, Necroptosis and Ferroptosis NECROSIS Necrotic cells stain eosinophilic and have a glassy homogenous appearance. Necrotic cells may also be calcified (dystrophic calcification). NECROSIS Normal Cell Necrotic Cell Loss of RNA (RNA stains basophilic) Increased and increase in denatured globulins eosinophilia Glycogen loss Homogeneous staining DNA damage in the necrotic cell Karyopicnosis Nucleus shrinkage and increased basophilia (also observed in apoptosis) Cariorexless: Fragmentation of the picnotic nucleus Cariolysis: Pale nucleus and loss of basophilia due to endonuclease- induced DNA loss TYPES OF NECROZES Coagulation Necrosis Other Types of Necrosis It develops after ischemia. There is enzymatic destruction. It is the most common type of necrosis. Ischemia ➔ Ph drop Enzyme and protein denaturation No enzymatic degradation TYPES OF NECROZES Coagulation Necrosis Other Types of Necrosis Likeifaction (liquefaction-melting) Necrosis The cell retains its integrity without being digested. (Cell roof is preserved) Gangrenous Necrosis Eosinophilic dead cells without nucleus Caseification Necrosis (Ghost cells) Fat Necrosis (Saponification Necrosis) Fibrinoid necrosis Other Types of Necrosis Likeifaction (liquefaction-melting) Necrosis Necrotic tissue has a liquitous viscous structure Abscess and central nervous system ischemia Ischemia of the lower extremities (Diabetic foot) ➔ Dry gangrene (Coagulation nec Gangrenous If accompanied by abscess ➔ Wet gangrene (Coagulation necrosis + Likeification Necrosis Caseification Necrosis Cheesy appearance In tuberculosis infections Fat Necrosis (Saponification traumatic fat necrosis and pancreatitis Necrosis) Fibrinoid necrosis Immune complex vasculitis (PAN)
