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Document Details

PrestigiousFermat

Uploaded by PrestigiousFermat

UDEM

Dr. Antonio Muñiz Buenrostro

Tags

complement system immunology biology medical notes

Summary

These are notes on the complement system, covering the classical and alternate pathways. The notes include diagrams and details on different components and regulatory mechanisms.

Full Transcript

8. The complement Dr. Antonio Muñiz Buenrostro REMEMBER...

8. The complement Dr. Antonio Muñiz Buenrostro REMEMBER 2 and 24 Leatic way note MBL asociated protect & means one : can sain complet Classical Alternate criquo/con active starts directly MBL antibodiea with 13 Pathway this : manose protein : is MASP whats spontaneous > is gonna this i thin - - activate the pathway Antigen-Antibody ↓ if factor negulated > - complex I is not 22 and (4 -> components = 2 = Cls 1 = (g 2 = (In C3C = autoimmunity MBL with the MASP proteins ① C3b binding ↳ deficiency difference 21 (only pathway that has it > - : complex opsonization endsa , ↓ of this For the complement 2 I factor · CY convertage exYo 23 activates C2 and C4 (see Lectin pathway a proteins to be activated letters ! activateswith spanter they need to be , - has Cl inhibitor another way C3- + hydrolyzed &3 ; < - + ~ Factor B we need it binding engmente - Ci to start the 24bp Factor 1 , MCP DAF CK1 they block 23 convertise hidrolized t ↓ geta : proces we - , , , or ↳ remember ↓ for this important exam the most C3i +B important - has [1 inhibitor protein actu Ba needs 24bp Factor ↓ ↳ - , 1 , MCP, DAF and (RT : blocks the (3i + Bb -> different 23 convertise it activat 2za tion) 1 convertas deficiency D inhibito angidema 23 convertase 23 - of can also blocked be I ↓ ↓ by Factor Cy activates Cyb binds inflamatory * convertase /1 to 25 to C5 convertase get -> Czb combe ↓ ↓ blockedefactori binds with to activate Factor blocks -4 1 : C3b convertise · CJ ↳ remember fr exam and activates · has Factor H a CD55 and it C5b CD35 ↓ ↓ ↓ activates (J gonnaas blocks MAC the zzconvertage and we get mac complex CTb(9 c5bC9 inhibite to Farmers Instead of using (2and 24 this ↑ un - · wer feeta wer feature inhibited circulatingeus ~nation ↑ CD59 and Vitronectin and these two eye 22 and C4 !!! Clusterin adding itself to the complex ↓ defcim to lead can more inflamation not is if C3a. blocked

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