4th Year Medicine Laboratory Medicine Course - Mineral Disorders PDF
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Uploaded by Deleted User
2023
Jehad Tayyeb
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Summary
This document is a lecture on mineral disorders for 4th-year medical students, focusing on magnesium, sodium, potassium, and calcium. It discusses normal and abnormal levels, associated disorders, and common laboratory tools.
Full Transcript
4th Year Medicine Laboratory Medicine Course Mineral disorders Assistant Prof. Jehad Tayyeb Clinical Biochemistry Department, 2023 Intended Learning Outcomes By the end of this lecture, the student will be able to: 1. Clarify the normal and abnorm...
4th Year Medicine Laboratory Medicine Course Mineral disorders Assistant Prof. Jehad Tayyeb Clinical Biochemistry Department, 2023 Intended Learning Outcomes By the end of this lecture, the student will be able to: 1. Clarify the normal and abnormal levels of plasma magnesium, sodium, potassium and calcium. 2. Explain the main disorders that associate with the mineral's abnormal levels. 3. Outline the common laboratory tools that used to estimate the minerals concentrations. Magnesium (Mg) Magnesium is the fourth abundant cation (Mg2+) in the body The total body content of Mg is 21 - 28 g Normal serum Mg 1.7 - 2.5 mg/dL Distribution of Mg in the body 53% 46% 1% Muscles and extracellularly in Is stored in bone soft tissues blood and RBCs Function of Mg: 1. The proper functioning of muscles and nerves. 2. It forms a complex with ATP and is an important cofactor for a wide range of enzymes, transporters, and nucleic acids required for normal cellular function, replication, and energy metabolism. 3. Important for the metabolism of sodium, potassium, calcium, vitamin C, and phosphorus. 4. Maintaining electrolyte balance 5. Anti-stress Hypomagnesemia Normal serum Mg = 1.7 - 2.5 mg/dL Definition: Clinically significant deficiency of
