Blood Transfusion Reactions PDF

22 Recipient of RBCs Recipient of Plasma 2_ Usually due to clerical error involving D 0 A B AB D 0 A B AB ABO system 0 0 X X X X 0 0 X n A...

22 Recipient of RBCs Recipient of Plasma 2_ Usually due to clerical error involving D 0 A B AB D 0 A B AB ABO system 0 0 X X X X 0 0 X n A X X D A J( X 3. Most common symptom-fever 0 B X X 0 B X X r r AB X AB X X X X 4. Physio]ogica] events a. Hemoglobinemia Special Considerations for the b. Hemoglobinuria Neonatal Crossmatch (< 4 months) c. Hyperbilirubinemia d. Can result in kidney failure and Initial sample from the infant shall be tested for ABO group (cell death type only) and Rh type. Test for unexpected antibodies can be done using neonate's or EXTRAVASCULAR HEMOLYTIC mother's serum or plasma. TRANSFUSION REACTION- DELAYED No crossmatch or repeat 1. Usually due to anamnestic r esponse to ABO/Rh tests for neonates clinically significant antibodies such as under 4 months is necessary Rh, Kell, Kidd and Duffy; usually during any hospitalization if occurs after transfusion completed initial antibody screen is negative using infant or 2. Delayed transfusion reactions maternal serum or plasma, aod a. Hours to days after transfusion group "O", ABO identical, or ABO compatible blood is given b. Indicated by NO rise or a t in and transfused cells are D hemoglobin after !transfusion compatible. c. Positive DAT (key characteristic) d. Often due to Kidd antibodies To issue non-O RBCs, not ABO compatible ivj,th maternal ABO, musL tes.f ft;,r passively acquired maternal ABO antibodies TRANSFUSION-RELATED ACUTE LUNG INJURY using antig1obulin pbase. (TRALI) If clinically slgnificant antibody exists, infant must get antigen 1. Acute respiratory insufficiency and negative blood or units crossmatch compatible by antiglobulin bilateral pulmonary edema by X-ray crnssmatch until antibody no longer detected. withouL cardiac failure; includes chiUs, fever, and hypo tension Infants weighing