Haemoglobin Expression PDF
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Uploaded by IrresistibleDune1507
University of Portsmouth
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Gavin Knight
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Summary
This presentation discusses the control of hemoglobin expression, focusing on developmental hemoglobin types, adult and fetal hemoglobin, and the order of hemoglobin activation based on gene location. It also covers the different types of hemoglobin and their structures, including Gower I, Gower II, Portland, fetal Hb, and adult Hb.
Full Transcript
Haemoglobin expression GAVIN KNIGHT Learning Objectives On completion of this session, you should be able to: 1. Differentiate between the structures of developmental haemoglobins 2. Compare and contrast adult (HbA) and foetal haemoglobin (HbF) 3. Explain the order of haemogl...
Haemoglobin expression GAVIN KNIGHT Learning Objectives On completion of this session, you should be able to: 1. Differentiate between the structures of developmental haemoglobins 2. Compare and contrast adult (HbA) and foetal haemoglobin (HbF) 3. Explain the order of haemoglobin activation based upon the location of the encoding genes Types of Haemoglobin Haemoglobin structure dependent on subunit composition Embryonic Hb: Gower I - 22 Portland - 22 Gower II - 22 Embryonic Hb only detectable for up to 8 weeks Foetus: HbF (22) comprises 90-95% up to 36 weeks Adult: HbA (22) detectable from 9 weeks gestation HbA2 (22) appears late in foetal life [HBA] in adults approx. 95% α [HbF] in adults usually
