Regional Immunity (MALT) PDF
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BAU Medical School
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Summary
This document provides an overview of regional immunity, specifically focusing on the mucosal immune system (MALT). It details various aspects, including different types of MALT regions (GALT, BALT, NALT, RALT), components like M cells, and the role of the immune system in the gastrointestinal tract. The document explains the innate and adaptive immune responses within the gut and explores the structure of Peyer's patches (PP).
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REGIONAL IMMUNITY (MALT) REGIONAL IMMUNITY MALT regions GALT Gut Associated Lymphoid Tissue BALT Bronchus Associated Lymphoid Tissue NALT Nasal Associated Lymphoid Tissue RALT Reproductive Associated Lymphoid Tissue GALT Gastrointestinal Tract Compartments GALT(MALT)...
REGIONAL IMMUNITY (MALT) REGIONAL IMMUNITY MALT regions GALT Gut Associated Lymphoid Tissue BALT Bronchus Associated Lymphoid Tissue NALT Nasal Associated Lymphoid Tissue RALT Reproductive Associated Lymphoid Tissue GALT Gastrointestinal Tract Compartments GALT(MALT) is organized for mainly sIgA production. System including 2 compartment: Induction site -Peyer patches, appendix, MLN, other LN Effector site -Lamina propria and its lymphocytes COMMON MUCOSAL IMMUNE SYSTEM PP STRUCTURE PP mainly divided 3 units : 1.Dome region 2.B lymphocyte region (Follicular germinal centers) 3.T lymphocyte region (Parafollicular zone) M CELLS IN THE SMALL INTESTINE CELLS IN THE GALT Innate Immunity in the Gastrointestinal Tract ◦ Intestinal epithelial cells lining the small and large bowel are an integral part of the gastrointestinal innate immune system, involved in responses to pathogens, tolerance to commensal organisms, and antigen sampling for delivery to the adaptive immune system in the gut ◦ Several different extensively glycosylated proteins, called mucins, form a viscous physical barrier that prevents microbes from contacting the cells of the gastrointestinal tract ◦ In healthy individuals, lamina propria DCs and macrophages in the gut inhibit inflammation and serve to maintain homeostasis
