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# Peripheral Blood Film Examination An important component in evaluating anemia is examining the peripheral blood film, focusing on red blood cell (RBC) diameter, shape, color, and inclusions. This helps verify automated analyzer results. Normal RBCs on a Wright-stained blood film are roughly uni...

# Peripheral Blood Film Examination An important component in evaluating anemia is examining the peripheral blood film, focusing on red blood cell (RBC) diameter, shape, color, and inclusions. This helps verify automated analyzer results. Normal RBCs on a Wright-stained blood film are roughly uniform, measuring 7 to 8 µm in diameter. Smaller cells (8 µm) are macrocytic. ## Table 16.2: Description of Red Blood Cell (RBC) Abnormalities and Commonly Associated Disease States | Disease State | Cell Description | Commonly Associated Disease States | |---|---|---| | Anisocytosis | Abnormal variation in RBC volume or diameter | Hemolytic, megaloblastic, iron deficiency anemias | | Macrocyte | Large RBC (>8 µm in diameter), MCV > 100 fL | Megaloblastic anemia | | Oval Macrocyte | Large oval RBC | Myelodysplastic syndromes, chronic liver disease, bone marrow failure, reticulocytosis | | Microcyte | Small RBC (