Pharmacology of Diabetes Mellitus PDF RCSI January 2024

RCSI Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn Pharmacology of Diabetes Mellitus Class Year 2 Course Endocrine and Breast module Lecturer Prof Steve Safrany 341 Date January 2024  Learning outcomes Describe the mechanism of ac...

RCSI Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn Pharmacology of Diabetes Mellitus Class Year 2 Course Endocrine and Breast module Lecturer Prof Steve Safrany 341 Date January 2024  Learning outcomes Describe the mechanism of action of insulin, and recognize its therapeutic and adverse effects Compare and contrast the different types of insulin preparations & regimens used to treat diabetes, and identify their advantages and disadvantages Discuss the potential future directions for insulin therapy in diabetes mellitus, including the development of new insulin formulations, devices, & technologies Recognize the principles of pharmacotherapy of type 2 diabetes, including the different classes of drugs, their mechanism of action, and adverse effects Evaluate the clinical efficacy of antidiabetic drugs, including their effects on glycemic control, weight, blood pressure, lipid profiles, and other outcomes Diagnosis  Type 2 vs type 1 diabetes Type 2 diabetes Type 1 diabetes Insulin resistance with Absolute insulin deficiency relative insulin deficiency Abrupt onset of hyperglycemia Hyperglycemia develops and propensity for the gradually with progressive development of DKA decline in beta-cell function (i.e., initially silent) Insulin required Can be treated with oral Associated with auto medications antibodies Associated with increasing Predominant type of diabetes age and obesity diagnosed in individuals