2024 DSUR3210 IWB PT01 PL03 Rev. Inflammation and Repair PDF

usethem as a checklist  multi factorial s thenharmful quolonged  multilobated neutrophils swelling work together whats the point in knowing all this hallmarks ofacute inflammation...

usethem as a checklist  multi factorial s thenharmful quolonged  multilobated neutrophils swelling work together whats the point in knowing all this hallmarks ofacute inflammation correspond to the vascular cellularchanges that occur in acute inflammation  of damage acuteinflamcanbe triggered of cell of threat aim of inflam response of tissue  such as traumatic thermal injury of a cardinal signs refer to featuresseen in acute inflamation  mediators throughsignaling suchas histamine easy 0  and proteins likeIgG designed to get basilar changes sight of injury cells into heckIBMs notes good refresher 7h r Purpose of this Slow down blood stasis  is molecule expressed eitheron adhesion endothelium or leakolytesurfers andact of infection as  Recording 1 Ien I As a resultof vascularchanges reality proteinfluidleakingstas 7 so  extravasation cartoon summarises  move down a chemical concentrated gradient role when theyarrive at siteof injury  increasedwaspermeability dueto duetovasodilation vasopermeabity tumor cancauseproblems if not regulated  fluid Iwateryproteinrich I like a clearwatteryfluid Igrimauls in body If I reactio Occurs resulting in  Fibrinous inflam if vessels become particularly permeable and fibrinogen leaksoutand if fibrinogen is contained within a cavity such as thepericardial cavityof hardthen its very difficult toeradicate and you get theaccumulation of fibrinand it can lead to a fibrinous reaction escape offibrin inside thepericardial cavity can result in Fibrin pericarditis inflammation you can see this in acute myocardial infarction Fibrinous inflammation tends to bereallycharacteristicof inflam responses within lining of bodycavitysuch as the pericardium andpleura Purulent I suppurative inflam tends to occur when there is prominent infection bybacteriathat can destroy tissues inflam this tends to produce a really exagerated response lots of neutrophils admix with a necrotictissue thatinfection cause producing FUS if this happens inside tissue containedwithin surround wall of healthy tissue lots of neutrophils 1 lots of dead tissue then an abscess can form which is a localised collection ofpuscaused by suppuration destroytissue andthey are a pyogenic bacteria becausethe eg staphylacorus produce tissue Necrosis and induces a purlent suppurative inflammation  ex macrophages lymphocytes B tells Tcells or Idiopathic  we se 101fiate G inflammation unlikeacutewhichhas the abilitytoresolve 3 base of repair  angiogenesis Bloodoodformatif in a synergisticway reaction causes prolongation ofthronil this it Tons  body response ball of war full ofcells interact witheach other prolonged chronic I  only know them be 9891 Ens 1 2 or 3 only cause  of epithelioid macrophages lymphocytes horseshoe shaped andrelated totuberclosis L hazardly awarsed caseosinflamation  this an attempt ofmonocytesto together lymphocytes interacting thatis difficultto eradict TheThrottleswithin tilts tonormal  Resolution means the return of fissue once its been through an acute inflam processes no scarring no feature thatthe tissue is abnormal Regeneration is process in which resolution occurs Organisation occurs whentissue is really damaged and its trying to repair itself through granulos tissueformation Scar formation are far to damaged to undergo regeneration so therefor resolution is not possible because they are to damaged this is wherescar formation occurs it involves process of organisation Fibrosis abnormal amount of collagen deposition in certain organs  mean the means some not like resolution  andcellscan divide to regenerate ifatt.ee se reiasidiifsue n'format randt occurs whenthere'smild enas damage severe sugiii.is sY a.ttstif Scar format  extra notes make sure that art is main template to study Regeration occurs if the tissues can repair itself damage is mild process in which results in resolution srocess by with tissues are damaged but they can return to normal only can occur if tissue has ability to produceits own cells thatcan divide or has stem cells and tissue is not damaged Scar formation occurs if tissues cant repair itself damage is severe m connective tissue deposition in resultof move severe tissue injury or in tissues that are unable to divide or posses stemcells  damaged doesnothaveeitheroftheseabilities no regeneration if tissue L very important in tissue  r integrityis fie at the not damage ightlobe of liver fe heras a resultof egenquationleft side of liver can compensatebut thisonly can happen when in this scenario the extracellular matrix is damaged as as as Thismeansextracellularmatrixisdamag e e Ith mosis suf.es dbssiav Similarly underlying tissue but if Sig then i i  Parenchyma occurs due to sina.sisfngtiiiit theconnectiveandsuppor tissue then saving occursthrough maintained functioncanstillbe toextentthat L dueto a coronaryartery air indules refairheartby acute chronic attimeto  results 7 7 asaredtofsiarti ssueformationweget. s 1 endpoint resulting is Scar formation if tissueinjury is verybig bring edges of wound together through contraction only in certaincases For chronic inflammation and Scar tissue formation Macrophages important for chronic inflam tissue formation MZ phenotype very important in tissuerepair fibrosis play a role in cleaving offending agents getsrid ofdead tissue provide growth factor for proliferation ofvarious cells secrete cytokines thatstimulate fibrolast proliferation and connective tissue synthesis 901 Ji us pathways J s at NJby J Ieairy.IM 2 I Is laydownroadto 91s finishers mediated 9196 sinfibrosist in an atteme totryandstart theinitialphases ofrepair why is it called  Granulation tissue Consists of a lot of new form vessels through angiogenesis and there is also in ammatory cells and loose connective tissue lay down. This is mainly to try to get the cells to area for repair and facilitate the area for a more established scar to mature and form TumorGrowthfactors β TGFsignals FB tolay down collagen Ensa a s as Primary Secondary  cutaneous conditions g ten becomes ischaemic Keloid and raised thick raise shift  is tissues as a resultof chronicdisease Fibrosis _within inflammation