1. Hb structure function TEST ONLY.pdf

Structure and Function of Hemoglobin Hemoglobin (Hb) Chromosome 16 codes for the alpha chains • Globular hemeprotein in RBCs Chromosome 11 codes for the beta chains • Transports oxygen/CO2 • 2 parts: o Globin: Made of 4 polypeptide chains: 2 alpha (on chromosome 16) and 2 beta (on chromosome 11) o H...

Structure and Function of Hemoglobin Hemoglobin (Hb) Chromosome 16 codes for the alpha chains • Globular hemeprotein in RBCs Chromosome 11 codes for the beta chains • Transports oxygen/CO2 • 2 parts: o Globin: Made of 4 polypeptide chains: 2 alpha (on chromosome 16) and 2 beta (on chromosome 11) o Heme: A complex of iron and protoporphyrin IX found in Mb and Hb § Functions as: — Electron carrier: Oxidation/reduction rxns — Part of an enzyme’s active site: catalase for hydrogen peroxide breakdown — Reversible oxygen binder: Oxygen transport within cardiac/skeletal muscle Steps of Heme formation (know highlights on scheme) Porphyrias • â heme synthesis • Genetically inherited (most autosomal dominant, but congenital is recessive) Tx of Porphyrias • Hemin (Fe3+) injection: â ALA synthase activity • Avoid Sunlight • Ingest Beta Carotene: is a Free radical scavenger