01-10 Signal Transduction F2024 Notes PDF

Assigned Groups: Unit 1 1 2 3 Angela Garcia-Tapia Aliyah Casayuran Serafina Ferruzzi Gerardo Gomora Raleigh Erickson Colin Pearson Kaimalino Ingram Alyssa Hackworth Leslie Pliego Herrera Raelyn Yasutake...

Assigned Groups: Unit 1 1 2 3 Angela Garcia-Tapia Aliyah Casayuran Serafina Ferruzzi Gerardo Gomora Raleigh Erickson Colin Pearson Kaimalino Ingram Alyssa Hackworth Leslie Pliego Herrera Raelyn Yasutake Milah Khan CJ Tamayose 4 5 6 Melanie Benner Kayley Chan-Ayala Keylin Broussard Madi Earley Ann-Mae DeGuzman Abigail Chavez Jolie Widaman David Juarez Savannah Martinez Ruiz Zander Woolsey RJ Lydon Nora Smith 7 8 9 Riley Camarillo Katelyn Hanks Kaleb Agarano Jaimen David Ava Hollenbeck Madelynn Fannin Jordan Ingram Zoe Ludwick Bryan Garcia Abi Morales Jeronimo Carlos Mota Kara Pham Announcements Metacognition 04 assignment due by Sunday - exam 1 prep: reflection on engagement and content, and plan for studying Unit 1 Exam on Friday, September 20th - CLASS tutoring (scheduling link on Moodle), drop-in hours Monday & Wednesday 7-9pm Unit 2 starts next Monday, September 23rd - new reading guide, new pre-class quiz - new assigned groups 01-10 Signal Transduction I. Cell Signaling II. Signal Transduction A. Examples of Signal Transduction 01-10 Signal Transduction Resources. 29 – 32 Learning Objectives. By the end of today, you should be able to: 15. Explain how cells communicate via small proteins or steroidal hormones. a. Compare and contrast autocrine, paracrine, and endocrine signaling in animals. b. Given the structure of a ligand, determine whether it is lipid- soluble or lipid-insoluble. c. Describe the way biological information is encoded in both a lipid-soluble and lipid-insoluble signaling pathway. d. Given a diagram of signal transduction, identify ligands, receptors, and phosphorylation cascades. I. Cell Signaling /No #  I. Cell Signaling amino acids (side chain): signaling molecules: ITONPOLARI IAPOLAR( - - = ALL , - - SOt NONPOLR NONPOLAR 1 - - (w4 % POLAR) ~ POLAR LAR I - 2 AT LEAST - i. ITAR) It's -- - : ONE POLAR POLAR ! ~ 20 NONPOLAR (230% POLAR) I. Cell Signaling Hold up your card so that your desired answer is located at the top edge of the card. ! Which term best describes this signaling molecule? H - HH - +CI H > - 2 ⑧ B) hydrophilic/polar 17 > 24 - LOTS OF POLAR BONDS  Levels of Biological Organization # Text: pg. 16 I. Cell Signaling INFO - SOURCE TARGET CELL · CELL SIGNALING MOLECULES S OA AFACT · : UNICELLULAR MULTICELLULAR I. Cell Signaling Hold up your card so that your desired answer is located at the top edge of the card. "/ ! ! mating factor is released by an !-type yeast cell and diffuses a short distance to signal to nearby yeast cells. Which type of signaling 8 is occurring? A) autocrine 4 : SELF B) paracrine 22 : NEXT/NEARBY 1 C) endocrine 7 WITHIN : %  INFORMATION FROM II. Signal Transduction I OUTSIDE TO INSIDE CELL I Q SIGNALING MOLECULE : LIGAND ryv ⑧ SIGNALING MOLECULE # INTRACELLULAR RECEPTOR XVNX ** XNUA MEMBRANE- BOUND (PROTEIN) RECEPTOR ↓ If ↓N ↓Y ! SIGNAL (PROTEIN) CASCADE LLGAND RECEPTOR + NOLIGAND NO RECEPTOR , = INFO INFO. BUT , DNA DNA Figure 11.12 Text: pg. 211 Figure 11.13 Text: pg. 245 II. Signal Transduction 8 x1 SIGNAL CASCADE IPHOSPHORYLATION ④ = ACTIVATION 00000000 0 = ADDING A Q ⑫QQQ x27 SIGNAL AMPLIFICATION = MORE INFORMATION A. Examples of Signal Transduction A. Examples of Signal Transduction Hold up your card so that your desired answer is located at the top edge of the card. ! Testosterone is released by leydig cells in the testes, enters the bloodstream, and - circulates to various target cells in the body, including muscle cells. Which type of signaling is occurring? A) autocrine & Away B) paracrine C) endocrine Really , Animal wiBloodstream A. Examples of Signal Transduction 1. The structure of testosterone is shown below. - ↑ POLAR I HYDROPHOBIC 50 + NONPOLAR = NONPOLAR 128% NONPOLAR a. Which class of biological macromolecules does testosterone belong to? (Circle one.) NUCLEIC ACID PROTEIN & LIPID 4 FUSED STEROID : RINGS b. Is testosterone able to pass through the phospholipid bilayer on its own or not? How can you tell? YES IT'S HYDROPHOBIC ! , A. Examples of Signal Transduction #l c. Choose the correct type of signaling below (lipid-soluble or lipid-insoluble), and label each of the components of testosterone signaling: testosterone ligand androgen receptor (intracellular or membrane) - phosphorylation cascade (if present) X TESTOSTERONE ANDROGE A. Examples of Signal Transduction 2. The structure of human epidermal growth factor (EGF) is shown below. a. Which class of biological macromolecules does EGF belong to? (Circle one.) NUCLEIC ACID O PROTEIN LIPID SQUIGGLY : RIBBON STRUCTURE b. Is EGF able to pass through the phospholipid bilayer on its own or not? How can you tell? NO , NEEDS RECEPTOR OR CHANNEL LARGE & POLAR BONDS ↳ BACKBONE & SIDE CHAINS A. Examples of Signal Transduction c. Choose the correct type of signaling below (lipid-soluble or lipid-insoluble), and label each of the components of EGF signaling: EGF ligand HER-2 receptor (intracellular or membrane) phosphorylation cascade (if present) X EGF HER-2 RECEPTOR PHOSPHORY