Which type of chromosomal mutation is indicated as the cause of Beta thalassemia?
Understand the Problem
The question asks about the type of chromosomal mutation that causes Beta thalassemia, a condition where the body cannot produce hemoglobin normally. We need to evaluate the provided options (translocation, inversion, insertion, and deletion) to determine which one is the most likely cause of Beta thalassemia.
Answer
Mutations in the HBB gene on chromosome 11.
Beta thalassemia is caused by mutations in the HBB gene on chromosome 11, which affects beta globin production.
Answer for screen readers
Beta thalassemia is caused by mutations in the HBB gene on chromosome 11, which affects beta globin production.
More Information
Beta thalassemia mutations can affect different aspects of beta globin production including transcription, translation, and stability.
Tips
It is important to note that while most beta thalassemia cases are caused by mutations in the HBB gene, other genetic factors can also contribute to the disease.
Sources
- Beta thalassemia: MedlinePlus Genetics - medlineplus.gov
- Beta Thalassemia (Cooley's Anemia) - chop.edu
- Beta thalassemia: MedlinePlus Genetics - medlineplus.gov
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