Which of the following statements is true regarding the Emax of different agonists? A) Emax is dependent on the concentration of the agonist used B) Emax can vary significantly wit... Which of the following statements is true regarding the Emax of different agonists? A) Emax is dependent on the concentration of the agonist used B) Emax can vary significantly with different conditions C) Emax is irrelevant when measuring agonist effects D) Emax is the same for all agonists despite differing potencies Read more

Understand the Problem

The question is asking about the concept of Emax in pharmacology, specifically how it relates to different agonists and the factors that influence it. It presents multiple statements regarding Emax and requires identification of the true statement among them.

More Information

Emax, or the maximal response that can be produced by a drug, depends on the receptor and agonist involved as well as the experimental conditions. This is why Emax can differ under varying conditions. The statement that Emax is the same for all agonists despite differing potencies is incorrect, as full agonists can have the highest Emax values, while partial agonists have lower Emax values.

Tips

Confusing Emax with EC50, which measures potency, is a common mistake.

Sources

• Concentration Response - an overview | ScienceDirect Topics - sciencedirect.com