Which of the following genital ulcer clinical vignettes would most likely yield these test results: Tzank preparation for multinucleated giant cells, culture of the virus, direct f... Which of the following genital ulcer clinical vignettes would most likely yield these test results: Tzank preparation for multinucleated giant cells, culture of the virus, direct fluorescent antibody studies to detect virus, or PCR to test for presence of viral DNA?
Understand the Problem
The question is asking which clinical vignette related to genital ulcers is most likely to yield positive test results for presence of viral DNA, based on the described tests such as Tzank preparation and PCR. The focus is on identifying the correct clinical scenario that would support these tests.
Answer
Option C: a 19-year-old man with recurrent painful vesicles and ulcers.
The scenario in which the clinical presentation and testing methods (multinucleated giant cells on Tzanck preparation, viral culture, DFA, and PCR for viral DNA) align is option C: a 19-year-old man with recurrent episodes of painful vesicles and ulcers on the glans, typical of Herpes Simplex Virus (HSV) infection.
Answer for screen readers
The scenario in which the clinical presentation and testing methods (multinucleated giant cells on Tzanck preparation, viral culture, DFA, and PCR for viral DNA) align is option C: a 19-year-old man with recurrent episodes of painful vesicles and ulcers on the glans, typical of Herpes Simplex Virus (HSV) infection.
More Information
Herpes Simplex Virus (HSV) typically presents with painful vesicles and ulcers on the genitals. The presence of multinucleated giant cells on a Tzanck smear is indicative of HSV.
Tips
Do not confuse recurring painful ulcers with painless ones, as painless usually hints at syphilis. Herpes lesions are often painful.
Sources
- Atlas of Dermatology in Internal Medicine - link.springer.com
- General Infectious Disease Question and Answer Items - PMC - pmc.ncbi.nlm.nih.gov
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