Which of the following drugs, due to its mechanism of action (assuming therapeutic doses), would have a pharmacokinetic drug-drug interaction with entacapone and tolcapone? This DD... Which of the following drugs, due to its mechanism of action (assuming therapeutic doses), would have a pharmacokinetic drug-drug interaction with entacapone and tolcapone? This DDI results in significantly reduced metabolism of certain neurotransmitters that would likely lead to a hypertensive crisis. Selegiline (Eldepryl) Phenelzine (Nardil) Memantine (Namenda) Donepezil (Aricept) Ropinirole (Requip)
Understand the Problem
The question is asking to identify which drug, when combined with entacapone and tolcapone, would result in significantly reduced neurotransmitter metabolism and potentially lead to a hypertensive crisis due to a pharmacokinetic drug-drug interaction.
Answer
Phenelzine (Nardil)
The correct answer is Phenelzine (Nardil). Both nonselective MAO inhibitors like Phenelzine and COMT inhibitors like entacapone and tolcapone inhibit catecholamine metabolism. Using them together can lead to dangerously high levels of catecholamines and a potential hypertensive crisis.
Answer for screen readers
The correct answer is Phenelzine (Nardil). Both nonselective MAO inhibitors like Phenelzine and COMT inhibitors like entacapone and tolcapone inhibit catecholamine metabolism. Using them together can lead to dangerously high levels of catecholamines and a potential hypertensive crisis.
More Information
Entacapone and tolcapone are COMT inhibitors used to treat Parkinson's disease.
Tips
It is important to consider drug interactions, especially when drugs share metabolic pathways or mechanisms of action.
Sources
- Comtan (entacapone) dosing, indications, interactions ... - Medscape - reference.medscape.com
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