Which of the following best describes the function of ABCA1 in cholesterol metabolism?
Understand the Problem
The question is asking about the function of ABCA1 (ATP-binding cassette transporter A1) in cholesterol metabolism. ABCA1 is a protein involved in transporting cholesterol and phospholipids out of cells, particularly to nascent high-density lipoprotein (HDL). The question requires you to identify the option that accurately describes this primary function of ABCA1.
Answer
ABCA1 mediates the efflux of cellular cholesterol and phospholipids to apolipoproteins, forming HDL and facilitating reverse cholesterol transport.
ABCA1 plays a crucial role in cholesterol metabolism by mediating the efflux of cellular cholesterol and phospholipids to apolipoproteins, particularly apoA-I, which is essential for the formation of high-density lipoprotein (HDL). This process is a key step in reverse cholesterol transport, removing excess cholesterol from peripheral tissues.
Answer for screen readers
ABCA1 plays a crucial role in cholesterol metabolism by mediating the efflux of cellular cholesterol and phospholipids to apolipoproteins, particularly apoA-I, which is essential for the formation of high-density lipoprotein (HDL). This process is a key step in reverse cholesterol transport, removing excess cholesterol from peripheral tissues.
More Information
ABCA1's function in reverse cholesterol transport is considered antiatherogenic, meaning it helps prevent the buildup of plaque in arteries. ABCA1 influences total body cholesterol metabolism.
Tips
A common mistake is to think ABCA1 directly breaks down cholesterol, but it primarily transports it.
Sources
- Regulation of ABCA1 Functions by Signaling Pathways - PMC - pmc.ncbi.nlm.nih.gov
- The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease - pmc.ncbi.nlm.nih.gov
- ABCA1 Is the cAMP-inducible Apolipoprotein Receptor That ... - sciencedirect.com
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