Which aspect of metabolic pathways would be most relevant for a researcher to consider when selecting a drug to inhibit a specific step?
Understand the Problem
The question asks which aspect of metabolic pathways is most relevant when a researcher wants to inhibit a specific step with a drug. The key is understanding how drugs interact with metabolic pathways to inhibit them.
Answer
Specificity for the target enzyme, potential off-target effects, and impact on overall metabolic flux.
When selecting a drug to inhibit a specific step in metabolic pathways, a researcher should consider the specificity of the drug for the target enzyme, potential off-target effects, and the impact on overall metabolic flux and related pathways.
Answer for screen readers
When selecting a drug to inhibit a specific step in metabolic pathways, a researcher should consider the specificity of the drug for the target enzyme, potential off-target effects, and the impact on overall metabolic flux and related pathways.
More Information
Drug metabolism is the process by which medications are broken down in the body. This usually occurs through specialized enzymatic systems. Understanding drug metabolism is essential for determining drug safety and efficacy.
Tips
A common mistake is to only consider the direct effect on the targeted step, neglecting the broader consequences on the metabolic network.
Sources
- Drug Metabolism - an overview | ScienceDirect Topics - sciencedirect.com
- Metabolic Inhibition - an overview | ScienceDirect Topics - sciencedirect.com
- Metabolic Control Analysis: A Tool for Designing Strategies to ... - pmc.ncbi.nlm.nih.gov
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