What triggers the release of ACTH from the anterior pituitary?
Understand the Problem
The question is asking about the factors that stimulate the release of ACTH (Adrenocorticotropic hormone) from the anterior pituitary gland, specifically identifying the one correct option from a multiple-choice list, with a focus on physiological and hormonal regulation.
Answer
CRH from the hypothalamus triggers ACTH release from the anterior pituitary.
The corticotrophin-releasing hormone (CRH) from the hypothalamus stimulates the anterior pituitary to release ACTH.
Answer for screen readers
The corticotrophin-releasing hormone (CRH) from the hypothalamus stimulates the anterior pituitary to release ACTH.
More Information
The release of ACTH (adrenocorticotropic hormone) is part of the hypothalamic-pituitary-adrenal (HPA) axis. CRH is released in response to low cortisol levels or stress, stimulating ACTH release which then stimulates cortisol production, closing the loop with a feedback mechanism.
Tips
A common misconception is that ACTH itself initiates the release of CRH, when it is actually the low cortisol levels or stress that stimulate CRH release.
Sources
- Adrenocorticotropic Hormone (ACTH): What It Is & Function - my.clevelandclinic.org
- Normal Physiology of ACTH and GH Release in the Hypothalamus - ncbi.nlm.nih.gov
- Adrenocorticotropic Hormone - yourhormones.info
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