What role does GLUT-4 play in glucose transport to skeletal muscle?
Understand the Problem
The question is asking about the function of GLUT-4 in the process of glucose transport specifically in skeletal muscle, particularly how it is influenced by insulin and exercise.
Answer
GLUT4 facilitates glucose transport to skeletal muscle by translocating to the plasma membrane upon muscle contraction or insulin stimulation.
GLUT4 facilitates glucose transport into skeletal muscle cells by translocating from intracellular storage to the plasma membrane and T-tubules upon muscle contraction or insulin stimulation, allowing glucose to enter cells through facilitated diffusion.
Answer for screen readers
GLUT4 facilitates glucose transport into skeletal muscle cells by translocating from intracellular storage to the plasma membrane and T-tubules upon muscle contraction or insulin stimulation, allowing glucose to enter cells through facilitated diffusion.
More Information
GLUT4 plays a crucial role in maintaining glucose homeostasis and has insulin-responsive characteristics, making it important for studies in diabetes and metabolic regulation.
Tips
A common mistake is confusing the role of GLUT4 with other glucose transporters which are not as responsive to insulin or muscle contraction.
Sources
- Current understanding of glucose transporter 4 expression and ... - pmc.ncbi.nlm.nih.gov
- GLUT4 - an overview | ScienceDirect Topics - sciencedirect.com
- Exercise, GLUT4, and Skeletal Muscle Glucose Uptake - journals.physiology.org
AI-generated content may contain errors. Please verify critical information
