What is the significance of peptide editing in MHC class 1 molecules?
Understand the Problem
The question is asking for the importance of peptide editing in MHC class 1 molecules and provides multiple choice answers to choose from. It aims to evaluate the understanding of MHC functioning in relation to immune response.
Answer
Peptide editing in MHC class I molecules helps the immune system recognize diseased cells.
Peptide editing in MHC class I molecules helps the immune system recognize diseased cells by presenting intracellular peptides, allowing for T cell surveillance and response against infections and tumors.
Answer for screen readers
Peptide editing in MHC class I molecules helps the immune system recognize diseased cells by presenting intracellular peptides, allowing for T cell surveillance and response against infections and tumors.
More Information
Peptide editing is crucial because it ensures MHC I molecules present high-affinity peptides that reflect the intracellular environment, thereby exposing tumor or pathogen-derived peptides to T cells.
Sources
- The web page with info on - ScienceDirect - sciencedirect.com
- Present Yourself! By MHC Class I and MHC Class II Molecules - NCBI - ncbi.nlm.nih.gov
- Molecular basis of MHC I quality control in the peptide loading - Nature - nature.com
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