What is the primary function of the TAP1/TAP2 transporter?
Understand the Problem
The question is asking about the main role of the TAP1/TAP2 transporter within a cell. The options provide different potential functions, and the correct answer will identify the specific process that this transporter is responsible for.
Answer
The TAP1/TAP2 transporter moves peptides from the cytosol to the endoplasmic reticulum, enabling them to bind to MHC class I molecules for immune presentation.
The primary function of the TAP1/TAP2 transporter is to transport peptides from the cytosol to the endoplasmic reticulum for loading onto MHC class I molecules, which is vital for cell surface presentation of intracellular peptides to cytotoxic T-cells.
Answer for screen readers
The primary function of the TAP1/TAP2 transporter is to transport peptides from the cytosol to the endoplasmic reticulum for loading onto MHC class I molecules, which is vital for cell surface presentation of intracellular peptides to cytotoxic T-cells.
More Information
TAP1 and TAP2 are two 'half transporter' members of the ABC superfamily. TAP1 and TAP2 form a heterodimer responsible for the ATP-dependent translocation of peptides across the endoplasmic reticulum membrane.
Tips
A common mistake is to confuse the direction of transport. TAP1/TAP2 transports peptides from the cytosol into the endoplasmic reticulum, not the other way around.
Sources
- TAP1 gene: MedlinePlus Genetics - medlineplus.gov
- TAP2 gene: MedlinePlus Genetics - medlineplus.gov
- The Transporter Associated With Antigen Processing (TAP) - molmed.biomedcentral.com
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