What is the MOST likely cause of agglutination with anti-A, anti-B, and anti-A,B reagents, as well as with screening cells in the antibody screen?
Understand the Problem
The question describes a situation in blood typing where a sample shows agglutination (clumping) with multiple reagents (anti-A, anti-B, anti-A,B) and screening cells. This indicates a discrepancy in the initial ABO typing and the antibody screen. The question asks to identify the most likely cause of this pattern.
Answer
The most likely cause is the presence of non-specific antibodies, or the presence of the corresponding antigen on the red blood cells being tested.
The most likely cause of agglutination with anti-A, anti-B, and anti-A, B reagents, as well as with screening cells in the antibody screen, is the presence of non-specific antibodies, or the presence of the corresponding antigen on the red blood cells being tested.
Answer for screen readers
The most likely cause of agglutination with anti-A, anti-B, and anti-A, B reagents, as well as with screening cells in the antibody screen, is the presence of non-specific antibodies, or the presence of the corresponding antigen on the red blood cells being tested.
More Information
Agglutination occurs when antibodies bind to antigens on red blood cells, causing them to clump together. This reaction is used in blood typing to determine a person's ABO blood group and Rh factor.
Tips
It is important to properly identify the cause of agglutination to ensure accurate blood typing and prevent transfusion reactions.
Sources
- Agglutination: What Is It, Purpose, and More - Osmosis - osmosis.org
- [PDF] Blood Grouping Reagents - FDA - fda.gov
- Antibody Screening - an overview | ScienceDirect Topics - sciencedirect.com
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