What is the action of ritonavir on HIV?
Understand the Problem
The question asks about the mechanism of action of the drug Ritonavir in the context of HIV treatment. It requires selecting the correct option that describes how Ritonavir affects the HIV virus.
Answer
Ritonavir inhibits HIV viral proteinase, used to boost other protease inhibitors by inhibiting cytochrome P450-3A4.
Ritonavir is an antiretroviral medication that inhibits the HIV viral proteinase enzyme, preventing the virus from replicating. It is often used to boost other protease inhibitors. Ritonavir inhibits cytochrome P450-3A4, reducing the breakdown of other protease inhibitors.
Answer for screen readers
Ritonavir is an antiretroviral medication that inhibits the HIV viral proteinase enzyme, preventing the virus from replicating. It is often used to boost other protease inhibitors. Ritonavir inhibits cytochrome P450-3A4, reducing the breakdown of other protease inhibitors.
More Information
Ritonavir was initially designed to inhibit HIV protease. It is now more commonly used to inhibit an enzyme called cytochrome P450-3A4.
Tips
It's easy to confuse Ritonavir's original purpose (inhibit HIV protease) with its more common current use (boosting other protease inhibitors). Pay close attention to the context to understand which action is being discussed.
Sources
- Ritonavir Patient Drug Record | NIH - Clinical Info HIV.gov - clinicalinfo.hiv.gov
- Ritonavir: Uses, Interactions, Mechanism of Action | DrugBank Online - go.drugbank.com
- Ritonavir - Aidsmap - aidsmap.com
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